Results 211 to 220 of about 106,006 (259)

Navigating uncertainty during non‐invasive prenatal testing: Genetic counselors' experiences of supporting autonomous reproductive decision‐making

Journal of Genetic Counseling, Volume 35, Issue 2, April 2026.
Abstract There is limited understanding of how healthcare professionals understand and apply the concept of reproductive autonomy in their clinical practice with non‐invasive prenatal testing (NIPT). Existing research indicates potential misalignment between theoretical understandings of reproductive autonomy and its operationalization by healthcare ...
Chanelle Warton, Danya F. Vears
wiley   +1 more source

Impact of Denosumab Adherence on Renal Function and Mortality Rates in Type 2 Diabetes Patients With Osteoporosis

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 4, April 2026.
ABSTRACT Type 2 diabetes mellitus (T2DM) is associated with an increased risk of osteoporosis and fractures, and denosumab, a non‐kidney‐excreted antiresorptive medication, represents a viable alternative to bisphosphonates for osteoporosis treatment in patients with T2DM. This study aimed to investigate the association among denosumab adherence, renal
Yu‐Chuan Chang, Jian‐Chih Chen, Sung‐Yen Lin, Kun‐Der Lin, Pei‐Shan Ho, Chung‐Hwan Chen, Yin‐Chih Fu, Tien‐Ching Lee   +7 more
wiley   +1 more source

International Registry of NKX2‐1‐Related Disorders: Clinical, Genetic, and Imaging Perspectives

Movement Disorders, Volume 41, Issue 4, Page 889-900, April 2026.
Abstract Background NKX2‐1–related disorders result from heterozygous variants in NKX2‐1, a gene crucial for brain, lung, and thyroid development. Although movement disorders, hypothyroidism, and neonatal respiratory distress are recognized, the full phenotype and genotype–phenotype relationships remain incompletely defined.
Laia Nou‐Fontanet, Claudia Ravelli, Lydie Burglen, Sol Balsells Mejia, Angel Valls‐Villalba, Elies Roman Schiffels, Alice Innocenti, Beatriz Villafuerte, Ainara Salazar‐Villacorta, Vicente Quiroz, Andrea Sariego Jamardo, Giulia Bonato, Asun Díaz‐Gomez, Alexandra Afenjar, Catheline Vilain, Patricia Dumke da Silva Möller, Deyanira Garcia‐Navas Nuñez, Magdalena Krygier, Maria Judit Molnar, Łukasz Milanowski, Katrin Õunap, Micaela Pauni, Patricia Vega, Raphael Borie, Milena Villamil‐Osorio, Sanem Yilmaz, Dénes Zádori, Marta Zawadzka, Tahsin Stefan Barakat, Sebastian Neuens, Daniel de Natera‐de Benito, Dídac Casas‐Alba, Luca Soliani, Claudio M. de Gusmao, Giacomo Garone, Nicola Specchio, Miryam Carecchio, José C. Moreno, Francesca Magrinelli, Kailash P. Bhatia, Darius Ebrahimi‐Fakhari, Claudia Castiglioni, Manju Ann Kurian, João Nuno Carvalho, Roser Pons, Emmanuel Roze, Diane Doummar, Juan Darío Ortigoza‐Escobar   +47 more
wiley   +1 more source

Association Between Thyroid Gland Volume and Postoperative Hypothyroidism Following Hemithyroidectomy

OTO Open, Volume 10, Issue 2, April-June 2026.
Abstract Objective To evaluate whether the proportion of resected thyroid tissue or the residual lobe volume predicts postoperative hypothyroidism following hemithyroidectomy. Study Design Multicenter retrospective cohort study. Setting Ziv Medical Center and Galilee Medical Center, Israel.
Mayas Arraf, Alaa Safia, Adi Sharabi‐Nov, Moanes Awad, Yaniv Avraham, Ohad Ronen, Shlomo Merchavy   +6 more
wiley   +1 more source

Amiodarone‐Induced Pulmonary Toxicity With Confirmed Elevated Plasma Mono‐Desethyl‐Amiodarone Levels

Respirology Case Reports, Volume 14, Issue 4, April 2026.
We report a case of pulmonary toxicity that developed 10 months after the initiation of amiodarone. The serum mono‐desethyl‐amiodarone concentration was elevated despite the relatively low cumulative amiodarone dose. ABSTRACT Amiodarone hydrochloride is an effective antiarrhythmic drug that can cause serious adverse effects, including amiodarone ...
Munechika Hara, Miki Kato, Fumika Sugiyama, Ryo Ichikawa, Tsutomu Hachiya   +4 more
wiley   +1 more source

Fibrosis‐Driven Surgical Risk After Thyroid Nodule Ablation: Quantitative Clinicopathological Determinants of Complications in Post‐Ablative Thyroidectomy—A Retrospective Cohort Study

World Journal of Surgery, Volume 50, Issue 4, Page 914-923, April 2026.
Thermal ablation is increasingly used for selected benign and low‐risk thyroid nodules, yet some patients still require thyroidectomy for regrowth, persistent symptoms, or new oncologic concern. The surgical and pathological impact of ablation‐induced remodeling remains incompletely defined.
Daqi Zhang, Alvino Boero, Giacomo Gazzano, Andrea Satta, Laura Fugazzola, Carla Colombo, Francesco Brucchi, Gianlorenzo Dionigi   +7 more
wiley   +1 more source

Iodine and selenium intakes and status and thyroid function in midlife women with low bread intakes in New Zealand

Nutrition &Dietetics, Volume 83, Issue 2, Page 258-266, April 2026.
Abstract Aims Iodine and selenium are important nutrients for thyroid function; however, the New Zealand food supply is generally low in both minerals. Bread can be a good source of these minerals; although the popularity of lower carbohydrate diets means some people avoid bread. This study aimed to investigate the effect of low bread intakes on iodine
Jaime Berger, Jacqueline Finlayson, Pamela R. von Hurst, Louise Brough   +3 more
wiley   +1 more source

Signal Amplification in the HPT Axis—Evidence for Its Existence, Location, Significance, and Molecular Mechanisms

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Thyroid hormones (THs) are under negative feedback regulation via the hypothalamic–pituitary‐thyroid (HPT) axis. How this axis operates to keep the circulating THs within a narrow physiological range is not well understood quantitatively. Led by the design principle of robust homeostatic feedback control, here we review and synthesize the ...
Li Jing, Sarahna A. Moyd, Qiang Zhang
wiley   +1 more source

Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone–Binding Globulin Expression

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.
ABSTRACT Sex hormone–binding globulin (SHBG) is a sex hormone carrier. We aimed to characterize the role of pregnane X receptor (PXR), a major regulator of drug metabolism, in SHBG regulation. Serum SHBG was measured in four clinical trials (n = 61) and expression in in vitro experiments in human 3D hepatocyte spheroids and HepG2 cells.
Maria H. Ahonen, Anja Konzack, Tomas Smutny, Petr Pavek, Jukka Hakkola, Janne Hukkanen   +5 more
wiley   +1 more source

Evaluating the Link Between Thyroid Function Test Results and Levothyroxine Dose in the Management of Hypothyroidism: Can We Improve Dosing Regimes?

Clinical Endocrinology, Volume 104, Issue 4, Page 372-385, April 2026.
ABSTRACT Introduction Over 10 million thyroid function tests (TFTs) are carried out in England each year, most requests coming from primary care. Our previous work showed that only 25% of results for patients being treated with Levothyroxine fell within the TSH/FT4 boundary circumscribing 75% of untreated individuals.
Adrian H. Heald, Lakdasa D. Premawardhana, Peter N. Taylor, Suhani Bahl, Onyebuchi E. Okosieme, Anthony A. Fryer, Antonio Bianco, Colin M. Dayan, Michael P. Stedman   +8 more
wiley   +1 more source