Results 221 to 230 of about 112,323 (327)

Safety Evaluation of Serendipity Berry Sweet Protein From Komagataella phaffii

open access: yesJournal of Applied Toxicology, Volume 45, Issue 8, Page 1455-1475, August 2025.
ABSTRACT Serendipity Berry Sweet Protein (sweelin) is a novel hyper‐sweet thermophilic protein designed using Artificial Intelligence Computational Protein Design (AI‐CPD) to improve the stability and sensory profile of the protein found in serendipity berry (Dioscoreophyllum cumminsii).
Yael Lifshitz   +12 more
wiley   +1 more source

Allergenicity, Genotoxicity and Subchronic Toxicity Assessment of IgG Binding Protein LT Produced From Aspergillus oryzae

open access: yesJournal of Applied Toxicology, Volume 45, Issue 8, Page 1614-1636, August 2025.
ABSTRACT Gastrointestinal health is one of the fastest growing areas in the food and beverage industry, as its importance to overall health and well‐being is becoming increasingly recognized. Immunoglobulins play a key role in protecting the gastrointestinal tract, and nonbovine sources of immunoglobulins (including camel milk, which has a long history
Kirt R. Phipps   +8 more
wiley   +1 more source

Differentiating the solution structures and stability of transthyretin tetramer complexed with tolcapone and tafamidis using SEC‐SWAXS and NMR

open access: yesJournal of Applied Crystallography, Volume 58, Issue 4, Page 1373-1383, August 2025.
The structures and stabilities of transthyretin tetramers and their complexes with tolcapone or tafamidis bound at the T4‐site, in aqueous solutions without and with 8 M urea, are revealed using SEC‐SWAXS and NMR.Human transthyretin (TTR) is a homotetrameric protein involved in transporting thyroxine (T4) and retinol‐binding protein within serum and ...
Orion Shih   +7 more
wiley   +1 more source

A case of hypopituitarism with pancytopenia cured by corticosteroid and thyroid hormone replacement therapy. [PDF]

open access: yesEndocrinol Diabetes Metab Case Rep
Mladenovic V   +7 more
europepmc   +1 more source

Circadian Gene BMAL1 Regulation of Cellular Senescence in Thyroid Aging

open access: yesAging Cell, Volume 24, Issue 8, August 2025.
BMAL1 downregulation during aging reduces NFKBIA expression, accelerating thyroid cellular senescence and impairing hormone synthesis. Circadian rhythm disruption exacerbates thyroid functional decline, highlighting the BMAL1‐NFKBIA axis as a key mediator of aging‐related thyroid dysfunction and offering insights for stabilizing thyroid health in aging
Dandan Zong   +4 more
wiley   +1 more source

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