Results 281 to 290 of about 108,632 (316)

Thyroxine

2016
Thyroxine (T4) is an iodinated amino acid derivative primarily synthesized in the thyroid epithelial cells. T4 is a major TH but less potent than 3,3′,5-triiodothyronine (T3). T4 has been thought to be a prohormone of the active form, T3. The fact that the binding affinity of nuclear thyroid hormone receptors (TRs) for T3 is one order of magnitude ...
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THYROXINE AND INSULIN INTERACTION

Canadian Journal of Biochemistry and Physiology, 1959
Rate of body weight gain of both the young chick and the young rat was markedly inhibited following ingestion of amounts of thyroxine which were greatly in excess of physiological requirements. The rate of body weight gain of the young rat was also markedly inhibited in alloxan diabetes.
Dorothy S. Dow, C.E. Allen
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Inheritance of Decreased Thyroxine-Binding by the Thyroxine-Binding Globulin1

The Journal of Clinical Endocrinology & Metabolism, 1964
Near absence of the thyroxinebinding by serum thyroxine-binding globulin (TBG) was found in 6 members of a family who displayed no clinical manifestations of thyroid disease. This protein-binding defect appears to be transmitted as a mendelian autosomal dominant. The decreased binding by TBG was associated with a decreased concentration of PBI (1.9–3.3
D D Patton, J. T. Dowling, J. T. Nicoloff   +2 more
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A radioimmunoassay for measurement of thyroxine in unextracted serum.

Journal of Clinical Endocrinology and Metabolism, 1972
A rapid, specific, precise and reproducible radioimmunoassay (RIA) for measurement of thyroxine (T4) in unextracted human serum is described. The procedure compares the ability of standards and unknowns to compete with radioactive T4 for binding sites on
I. Chopra
semanticscholar   +1 more source

Cardiovascular Effects of Thyroxine

Cardiovascular Research, 1969
The chronic administration of relatively small doses of thyroxine to cats and guinea-pigs gave rise to an increased excitability of the heart associated with an increased sensitivity to vagal stimulation, an increased mitochondrial respiration and phosphorylation, and an increase in mitochondrial mass.
Zaimis, E., Papadaki, L., Ash, A.S.F., Larbi, E., Kakari, S., Matthew, M., Paradelis, A.   +6 more
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Altered intestinal absorption of L-thyroxine caused by coffee.

Thyroid, 2008
OBJECTIVE To report eight case histories, and in vivo and in vitro studies showing coffee's potential to impair thyroxine (T4) intestinal absorption.
S. Benvenga, L. Bartolone, M. A. Pappalardo, A. Russo, D. Lapa, G. Giorgianni, Giovanna Saraceno, F. Trimarchi   +7 more
semanticscholar   +1 more source

L-Thyroxine therapy in subclinical hypothyroidism. A double-blind, placebo-controlled trial.

Annals of Internal Medicine, 1984
The indications for treating patients with subclinical hypothyroidism (normal serum thyroxine and free thyroxine levels, but elevated serum thyrotrophin levels) are poorly defined.
D. Cooper, R. Halpern, L. C. Wood, A. Levin, E. Ridgway   +4 more
semanticscholar   +1 more source

Isolated Thyroxine Malabsorption Treated With Intramuscular Thyroxine Injections

The American Journal of the Medical Sciences, 2009
An 18-year-old girl with multiple autoimmune endocrinopathies was referred to the endocrinology clinic for management of hypothyroidism. She required increasing doses of thyroxine but remained hypothyroid. Daily and weekly supervised thyroxine administration strategies were unsuccessful.
Niru Goenka, Vinod Patel, Franklin Joseph, Lydia Anderson   +3 more
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Effects of Clofibrate (Atromid S) on the Thyroxine-Binding Capacity of Thyroxine-Binding Globulin and Free Thyroxine

The Journal of Clinical Endocrinology & Metabolism, 1969
ABSTRACT Estimations of the maximum thyroxine binding capacity of thyroxine-binding globulin (TBG) and of the free thyroxine fraction were undertaken in 12 patients with hyperlipoproteinemia, comprising 9 males and 3 females, who were receiving the hypocholesterolemic drug clofibrate (Atromid S).
R. L. Scott, R. I. Levy, S. P. Asper, C. G. McKERRON   +3 more
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DIAGNOSTIC VALUE OF SERUM THYROXINE AND FREE THYROXINE INDEX

Acta Medica Scandinavica, 1973
Abstract. A modified method for determination of serum total thyroxine (T4) using competitive protein‐binding is reported. This method proved particularly valuable when analysing a large number of serum samples. A clinical evaluation of T4 was performed in various thyroid disorders.
B.‐A. Lamberg, K. Liewendahl, R. Ruutu
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