Results 301 to 310 of about 112,323 (327)
Some of the next articles are maybe not open access.
European Journal of Nuclear Medicine, 1983
Free T4 calculation was performed based on the equation of the law of mass action between T4 and TBG assessed by routine radioimmunoassay. To examine the validity of this calculation, sera from normal subjects, from hypo- and hyperthyroid patients, from subjects with hereditary deficiency or increase in TBG, and those from uncomplicated pregnancy were ...
Natsuko Ohtsuki +2 more
openaire +3 more sources
Free T4 calculation was performed based on the equation of the law of mass action between T4 and TBG assessed by routine radioimmunoassay. To examine the validity of this calculation, sera from normal subjects, from hypo- and hyperthyroid patients, from subjects with hereditary deficiency or increase in TBG, and those from uncomplicated pregnancy were ...
Natsuko Ohtsuki +2 more
openaire +3 more sources
Thyroxine-protein interactions
Biochimica et Biophysica Acta (BBA) - Protein Structure, 1978The binding constants for interaction of various thryoxine analogues with the thyroxine binding site on human thyroxine-binding globulin have been determined. Equilibrium dialysis, at pH 7.4 and 37 degrees C, was used to measure the competitive effects of different iodothyronine compounds on the binding of 125I-labeled thyroxine to highly purified ...
Ladislav Korcek, Milton Tabachnick
openaire +3 more sources
Studies on thyroxine-binding globulin
Biochimica et Biophysica Acta (BBA) - Protein Structure, 1972Abstract 1. 1.|The quenching of thyroxine-binding globulin intrinsic protein fluorescence by ligands was used to demonstrate the binding of 0.85 ± 0.06 mole of thyroxine per mole of purified thyroxine-binding globulin and 0.91 ± 0.06 mole of triiodothyronine per mole of thyroxine-binding globulin. 2.
James S. Marshall +7 more
openaire +3 more sources
The Journal of Clinical Endocrinology & Metabolism, 1971
ABSTRACT Studies were conducted concerning the relation between TT4 and AFT4 in a family with TBG deficiency, consisting of 8 affected and 16 unaffected members, and in a group of 48 normals. A highly significant positive relationship between these 2 parameters was found within the family, as well as within the group of normals.
G. Hennemann, Roelof Docter, A. Dolman
openaire +3 more sources
ABSTRACT Studies were conducted concerning the relation between TT4 and AFT4 in a family with TBG deficiency, consisting of 8 affected and 16 unaffected members, and in a group of 48 normals. A highly significant positive relationship between these 2 parameters was found within the family, as well as within the group of normals.
G. Hennemann, Roelof Docter, A. Dolman
openaire +3 more sources
2016
Thyroxine (T4) is an iodinated amino acid derivative primarily synthesized in the thyroid epithelial cells. T4 is a major TH but less potent than 3,3′,5-triiodothyronine (T3). T4 has been thought to be a prohormone of the active form, T3. The fact that the binding affinity of nuclear thyroid hormone receptors (TRs) for T3 is one order of magnitude ...
openaire +2 more sources
Thyroxine (T4) is an iodinated amino acid derivative primarily synthesized in the thyroid epithelial cells. T4 is a major TH but less potent than 3,3′,5-triiodothyronine (T3). T4 has been thought to be a prohormone of the active form, T3. The fact that the binding affinity of nuclear thyroid hormone receptors (TRs) for T3 is one order of magnitude ...
openaire +2 more sources
Thyroxine binding and deiodination of thyroxine by human lymphocytes
Clinica Chimica Acta, 1978Binding and deiodination of T4 by lymphocytes from euthyroid, hypothyroid and hyperthyroid subjects were studied. Two sets of binding sites were found on normal lymphocytes. One set with equilibrium association constant of 6.9 X 10(9) l/mol and a maximal binding capacity of 3000 mol T4 per lymphocyte, and another set with equilibrium association ...
openaire +3 more sources
THYROXINE AND INSULIN INTERACTION
Canadian Journal of Biochemistry and Physiology, 1959Rate of body weight gain of both the young chick and the young rat was markedly inhibited following ingestion of amounts of thyroxine which were greatly in excess of physiological requirements. The rate of body weight gain of the young rat was also markedly inhibited in alloxan diabetes.
Dorothy S. Dow, C.E. Allen
openaire +3 more sources
Inheritance of Decreased Thyroxine-Binding by the Thyroxine-Binding Globulin1
The Journal of Clinical Endocrinology & Metabolism, 1964Near absence of the thyroxinebinding by serum thyroxine-binding globulin (TBG) was found in 6 members of a family who displayed no clinical manifestations of thyroid disease. This protein-binding defect appears to be transmitted as a mendelian autosomal dominant. The decreased binding by TBG was associated with a decreased concentration of PBI (1.9–3.3
D D Patton +2 more
openaire +3 more sources
Cardiovascular Effects of Thyroxine
Cardiovascular Research, 1969The chronic administration of relatively small doses of thyroxine to cats and guinea-pigs gave rise to an increased excitability of the heart associated with an increased sensitivity to vagal stimulation, an increased mitochondrial respiration and phosphorylation, and an increase in mitochondrial mass.
Zaimis, E. +6 more
openaire +3 more sources
Isolated Thyroxine Malabsorption Treated With Intramuscular Thyroxine Injections
The American Journal of the Medical Sciences, 2009An 18-year-old girl with multiple autoimmune endocrinopathies was referred to the endocrinology clinic for management of hypothyroidism. She required increasing doses of thyroxine but remained hypothyroid. Daily and weekly supervised thyroxine administration strategies were unsuccessful.
Niru Goenka +3 more
openaire +3 more sources