Results 101 to 110 of about 4,397 (276)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Classifying thyroid nodules with the American College of Radiology Thyroid Imaging Reporting and Data System: A simple and cost-effective approach for assessing malignancy risk

Current Medicine Research and Practice
Background: Thyroid nodules are common, with up to 68% of adults having them. Ultrasonography is commonly used to examine them, but cannot determine if they are benign or malignant.
Pavani Muthoju, Rabiya Baseri Nelofar, Pravalya Chaparala   +2 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Biomarkers of microvascularture by ultra Micro-angiography (UMA) assist to identify papillary thyroid carcinoma (PTC) with atypia of undetermined significance

BMC Cancer
Background It is challenging to identify Papillary Thyroid Cancer (PTC) which shows atypia of undetermined significance (AUS) by Fine-needle Aspiration (FNA).
Qingsong Wang, Zhewei Li, Jie Zhang, Sijie Zhang, Lijun Wang, Hongjian Yao, Hong Zhang, Jing Li, Shuo Wang, Jinglai Sun, Wenhui Zhang, Hui Yu   +11 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Correlação entre critérios ultrassonográfico ACR TI-RADS e Citopatológico Bethesda na avaliação de nódulos tireoidianos [PDF]

, 2018
INTRODUÇÃO: Nódulos tireoidianos são bastante comuns na população, entretanto, distinguir os nódulos tireoidianos malignos dos benignos constitui um desafio. A ultrassonografia (US) é uma ferramenta fundamental no diagnóstico do câncer de tireoide.
Lima e Silva, José Maria Correia, Rocha, Iara Patrícia Moura, Soares, Deydson Rennan Alves   +2 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Оn the need to introduce the TI-RADS classification in Russia

Клиническая и экспериментальная тиреоидология, 2019
An active discussion of TI-RADS modifications (Thyroid Imaging Reporting And Diagnostic System) classification continues in the world professional medical community.
Elena P. Fisenko, Alexander N. Sencha, Alexey N. Katrich, Yulia P. Sych, Nadezhda V. Tsvetkova, Alexey V. Borsukov, Ekaterina V. Kostromina   +6 more
doaj   +1 more source

Diffuse C-Cells Hyperplasia Is the Source of False Positive Calcitonin Measurement in FNA Washout Fluids of Thyroid Nodules: A Rational Clinical Approach to Avoiding Unnecessary Surgery [PDF]

Purpose: The FNA-CT is useful for the diagnosis of MTC. The aim of this study was to evaluate the performance of FNA-CT in TNs coexisting with CCH.
Antonello Cappai, Chiara Mura, Fabio Medas, Francesco Boi, Gian Luigi Canu, Maria Letizia Lai, Pietro Giorgio Calò, Rossella Rodia, Silvia Corrias, Stefano Mariotti   +9 more
core   +1 more source