Results 111 to 120 of about 4,397 (276)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Avaliação combinada do escore TI-RADS e classificação da ata com o sistema Bethesda para estratificação de risco de malignidade em nódulos tireoidianos com resultado citológico indeterminado [PDF]

, 2018
Orientadora: Prof. Dra. Gisah Amaral de CarvalhoCoorientadores: Prof. Dr. Cleo Otaviano Mesa Jr., Prof. Dra. Teresa Cristina CavalcantiDissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa de Pós-Graduação em ...
Lozovoy, Thayse Graciella Batisti
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Cytologically indeterminate thyroid nodules: increased diagnostic performance with combination of US TI-RADS and a new scoring system

Scientific Reports, 2017
To investigate the diagnostic performance of combination of ultrasound (US) thyroid imaging reporting and data system (TI-RADS) and a new US scoring system for diagnosing thyroid nodules (TNs) with indeterminate results (Bethesda categories III, IV and V)
Ya-Ping He, Hui-Xiong Xu, Chong-Ke Zhao, Li-Ping Sun, Xiao-Long Li, Wen-Wen Yue, Le-Hang Guo, Dan Wang, Wei-Wei Ren, Qiao Wang, Shen Qu   +10 more
doaj   +1 more source

Nódulos tiroideos y predisposición al desarrollo de cáncer tiroideo. Hospital Provincial General Docente Riobamba 2018 [PDF]

, 2019
Introduction: Worldwide thyroid cancer (TC) has an approximate incidence of 9 cases per 100 000 inhabitants, the highest incidence is observed in women at 40 years.
Badillo Pazmiño, Francisco Xavier, Ponce Pumalema, Fabiola Elizabeth   +1 more
core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

A study on the correlation of thyroid nodules with METS-IR and SII in a population undergoing health checkups

Frontiers in Endocrinology
ObjectiveTo investigate the associations between thyroid nodules and two emerging biomarkers-Metabolic Score for Insulin Resistance (METS-IR) and Systemic Immune-Inflammation Index (SII)-in adults undergoing routine health checkups.MethodsIn this ...
Ruoping Guan, Guokui Dai, Chuanjiang Ye, Xiangsheng Cai   +3 more
doaj   +1 more source

Concordancia diagnóstica entre la ecografía tiroidea y los estudios citopatológicos en nódulos de tiroides [PDF]

, 2021
Se reconoce a la biopsia por aspiración con aguja fina como elemento diagnóstico de elección ante la presencia de nódulos tiroideos, pues resulta útil en la determinación de malignidad.
Deza Tarrillo, Nogui Emil, Deza Tarrillo, Nogui Emil   +1 more
core  

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source