Results 121 to 130 of about 4,397 (276)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Diagnostic performance of the ACR TI-RADS classification in identifying and excluding thyroid malignancy: a multi-correlative retrospective study in a South African tertiary hospital

The Egyptian Journal of Radiology and Nuclear Medicine
Background Thyroid nodule evaluation is essential to exclude malignancy. The American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) stratifies malignancy risk based on sonographic features, guiding biopsy decisions and ...
Neelam Bagratee, Tanusha Sewchuran
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Preliminary analysis of AI-based thyroid nodule evaluation in a non-subspecialist endocrinology setting [PDF]

Producción CientíficaPurpose Thyroid nodules are commonly evaluated using ultrasound-based risk stratification systems, which rely on sub- jective descriptors.
Delgado García, Esther, Díaz Soto, Gonzalo, Estévez Asensio, Lucía, Fernández Velasco, Pablo, Gómez Hoyos, Emilia, Luis Román, Daniel Antonio de, Ortolá Buigues, Ana, Torres Torres, Beatriz   +7 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Biopsy or no biopsy? Risk of Malignancy in Thyroid Nodules Based on TI-RADS Criteria [PDF]

Purpose: To assess the risk of malignancy in thyroid nodules recommended for biopsy using the American College of Radiology (ACR) Thyroid Imaging Reporting & Data System (TIRADS). Methods: We conducted a retrospective review of ultrasound (US) guided
Halappa, Vivek, Shariff, Faadil
core   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

DETEKSI DINI KELAINAN INTRA-ABDOMEN DAN MUSKULOSKELETAL DENGAN PENAPISAN ULTRASONOGRAFI PADA LANSIA DI PANTI WERDHA MARFATI TANGERANG BANTEN [PDF]

Populasi lansia di dunia meningkat secara pesat, yang berdampak pada meningkatnya prevalensi penyakit seiring berjalannya waktu. Nyeri pada regio abdomen dan muskuloskeletal merupakan salah satu keluhan yang sering dialami oleh lansia.
Adonai, Amabel, Barus, Jimmy Fransisco Abadinta, Charlee, Michaela Alexandra, Gracia, Isadora, Indrawan, Novelya, Kosim, Fellicia Angelitha, Ronny, Ronny, Saputro, Aimee Aurelia, Sidharta, Veronika Maria, Simargi, Yopi, Sudiyono, Nelson, Susilo, Fenny   +11 more
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source