Results 81 to 90 of about 4,397 (276)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Comparative analysis of the diagnostic efficiency of the four thyroid imaging reporting and data systems

WFUMB Ultrasound Open
The purpose of this study was to comparative analyze the diagnostic efficiency of Thyroid Imaging Reporting and Data System proposed by Kwak, American College of Radiology, the European Thyroid Association and the Chinese Medical Association ...
Jun Xu, Wei-Bing Zhang, Wen-Fang Deng, Bei-Li He, Ting-Yue Qi   +4 more
doaj   +1 more source

Clinico-cytopathological subcategorization in thyroid nodules of atypia of undetermined significance/follicular lesion of undetermined significance using the TIRADS and Bethesda classifications

Frontiers in Endocrinology, 2023
IntroductionBethesda category III – atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is a heterogeneous class of the Bethesda system for thyroid nodules. In order to clarify the therapeutic road for clinicians,
Amirhesam Babajani, Amirhesam Babajani, Saeed Rahmani, Saeed Rahmani, Masoomeh Raoufi, Elham Shaarbaf Eidgahi, Amirreza Vahid Dastjerdi, Poya Behfarnia, Shayesteh Khalili, Noushin Afshar Moghaddam   +9 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Eficacia comparativa de la ecografía tiroidea y el estudio citopatológico de biopsia por aspiración con aguja fina en pacientes con nódulos tiroideos realizado en el Hospital Regional del Cusco 2014 – 2019 [PDF]

, 2023
Objetivo: Comparar la eficacia de la ecografía tiroidea con el estudio citopatológico de biopsia por aspiración con aguja fina en pacientes con nódulos tiroideos realizado en el Hospital Regional del Cusco 2014 – 2019 Métodos: Estudio descriptivo ...
Alvarado Chuctaya, Nefi Tom, Suyo Castillo, Derly   +1 more
core  

Hürthle cell neoplasms of the thyroid: Pathologic outcomes and ultrasonographic analysis [PDF]

, 2020
Background: Fine-needle aspiration (FNA) of thyroid nodules suspicious for Hürthle cell neoplasms (HCN) have uncertain rate of malignancy. We aim to characterize rate and predictors of malignancy at our institution and compare these findings with ...
Murthy, Henna D., Rabbani, Cyrus C., Shin, Timothy J., Sim, Michael W., Traylor, Katie   +4 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Diagnostic Accuracy of American College of Radiology Thyroid Imaging Reporting Data System

Journal of the ASEAN Federation of Endocrine Societies
Objective. This study aims to evaluate the diagnostic accuracy of the American College of Radiology Thyroid Imaging Reporting Data System (ACR TI-RADS) in identifying nodules that need to undergo fine-needle aspiration biopsy (FNAB) and identify ...
Pamela Ann Aribon, Emmylou Teope, Anna Lyn Corneja-Egwolf, Maria Patricia Deanna Maningat   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

New Proposed Formula of TI-RADS Classification Based on Ultrasound Findings

Acta Endocrinologica (Bucharest), 2020
The present study aimed to introduce a new formula for classification of nodules in TI-RADS and describe ultrasonography features of benign and malignant thyroid nodules.This study was conducted on thyroid mass in 1033 patients. The incidence of malignancy for thyroid nodules was determined by selecting malignancy coefficients.
S, Rahemi Karizaki, S A, Alamdaran, S, Bonakdaran, N, Morovatdar, A H, Jafarain, A, Sharifi Hadad, A, Hadadzade   +6 more
openaire   +3 more sources