Results 41 to 50 of about 80,863 (300)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

High Temperature Low Cycle Fatigue Properties and Failure Mechanism of a TiAl Alloy

Journal of Aeronautical Materials, 2017
Total strain range controlled low cycle fatigue (LCF) experiments were conducted at 750 ℃ to investigate the effects of the duplex and fully lamellar microstructure on fatigue behavior and life of a TiAl alloy, and the total strain range-life equation ...
DONG Chengli, YU Huichen, JIAO Zehui, KONG Fantao, CHEN Yuyong   +4 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Tailoring the Microstructure of Laser-Additive-Manufactured Titanium Aluminide Alloys via In Situ Alloying and Parameter Variation

Metals, 2023
Titanium aluminide (TiAl) alloys have emerged as promising materials for high-temperature applications due to their unique combination of high-temperature strength, low density, and excellent oxidation resistance.
Igor Polozov, Victoria Sokolova, Anna Gracheva, Anatoly Popovich   +3 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Research progress in thermomechanical treatment process of TiAl alloys

Journal of Aeronautical Materials
TiAl alloys have attracted much attention due to its excellent specific strength，specific stiffness，and high-temperature performance，which has great potential for application in the aerospace industry.
WANG Yan, LUO Yaofeng, HE Jingjun, HU Qing, LIU Bin, LIU Yong   +5 more
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Positive effects of pre-oxidation on high temperature oxidation behavior of TiAl composites with multilayered structure

Journal of Materials Research and Technology
In order to study the pre-oxidation on high temperature oxidation behavior of TiAl composites with high-efficiency, the TiAl composites with multilayered structure were successfully prepared via spark plasma sintering (SPS) by introducing 0.5 wt% BN, 0.5 
Junqin Wu, Yupeng Wang, Genhua Zeng, Xiaohong Wang, Lei Li, Meng Li, Tengfei Ma   +6 more
doaj   +1 more source

On high-speed turning of a third-generation gamma titanium aluminide [PDF]

, 2012
Gamma titanium aluminides are heat-resistant intermetallic alloys predestined to be employed in components suffering from high mechanical stresses and thermal loads.
Martin Arft, Lung, Dieter, Klocke, Fritz, Priarone, Paolo Claudio, Fritz Klocke, Paolo Claudio Priarone, Arft, Martin, Dieter Lung, Settineri, Luca   +8 more
core   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source