Results 291 to 300 of about 319,939 (360)

Minimal invasive open tibial fracture model in mice. [PDF]

open access: yesInt Orthop
Hoelscher-Doht S   +7 more
europepmc   +1 more source

Target Binding of Black Phosphorus Nanomaterial to Polo‐Like Kinase 1 for Cancer Chemotherapy: A Mutual Selection of Nanomaterial and Protein

open access: yesExploration, EarlyView.
This study investigates the effect of protein properties on the nanomaterial‐protein interaction and elucidates the molecular mechanisms underlying the targeted inhibition of polo‐like kinase (PLK1) by black phosphorus nanomaterials (BPNMs). The specific targeting inhibition is attributed to the intrinsic properties of both the PLK1 protein and the ...
Fangfang Liu   +15 more
wiley   +1 more source

Personalized Cancer Immunotherapy Boosted by cGAS‐STING‐Targeted Nanovaccines in Combination With Nutrient Modulation

open access: yesExploration, EarlyView.
The engineered bacteria (2'3'‐cGAMP@E.coli) is designed to synthesize intracellular 2'3'‐cGAMP, enabling the assembly of personalized nanovaccines (nECTs) through a bioconjugation with autologous tumor antigens, circumventing elaborate chemical production processes. The therapeutic impact of nECTs is significantly amplified when combined with a fasting‐
Wenping Huang   +7 more
wiley   +1 more source

Multi‐Energy Integrated Photocatalysis for Antitumor Therapy

open access: yesExploration, EarlyView.
This comprehensive review summarizes recent advancements in piezo‐photocatalysts and photothermal‐photocatalysts for cancer therapy. It begins by outlining the principles of piezo‐photocatalysis and photothermal‐photocatalysis, followed by a discussion of various multi‐energy integrated photocatalysts designed for single‐, dual‐, triple‐, and tetra ...
Li Zhang   +4 more
wiley   +1 more source

Long term outcome after tibial shaft fracture: is malunion important? [PDF]

open access: yes, 2002
Davis, TRC   +4 more
core  

Integrative Evidence From Metabolome‐Wide Mendelian Randomization and Animal Models Implicates Tyrosine in Cardiac Hypercontractility and Arrhythmia Risk

open access: yesFood Frontiers, EarlyView.
Plasma metabolome‐wide Mendelian randomization analysis established a causal link between tyrosine and arrhythmia. GWAS meta‐analysis identified tyrosine‐associated loci linked to cardiovascular risk factors. Animal studies confirmed that oral tyrosine intake modulates heart rhythm via adrenergic signaling activation.
Zhikang Cao   +7 more
wiley   +1 more source

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