Results 211 to 220 of about 315,798 (254)

YTHDF3 Enhances Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoporosis by Promoting TBX19 Expression

open access: yesCell Proliferation, EarlyView.
In this study, OP‐BMSCs were successfully isolated from OVX osteoporotic rats. Mechanistic investigations revealed that the RNA‐binding protein YTHDF3 significantly upregulates Tbx19 expression by enhancing the stability of Tbx19 mRNA. Elevated Tbx19 levels, in turn, activate key osteogenic molecules, effectively promoting the differentiation of OP ...
Qianke Tao   +9 more
wiley   +1 more source

Soluble Epoxide Hydrolase Inhibition Regulates Septoclast Activity to Promote Long Bone Growth and Fracture Healing by Enhancing Endothelial‐to‐Mesenchymal Notch Signalling

open access: yesCell Proliferation, EarlyView.
The sEH inhibitor TPPU upregulates endothelial HIF‐1α, activating the NOTCH signalling pathway between endothelial cells and mesenchymal stem cells. This promotes the differentiation and formation of FABP5+ septoclasts, enhances their participation in endochondral ossification, and ultimately improves longitudinal bone growth and fracture healing ...
Weixian Chen   +10 more
wiley   +1 more source

International consensus recommendations for identifying malnutrition in children with neurological impairment

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Abstract Children with neurological impairment (CNI) are at increased risk of malnutrition because of functional, medical, and socioeconomic challenges. However, difficulties in obtaining reliable anthropometric measurements and differences in body composition limit the usefulness of conventional nutritional indicators.
Sarah Vermilyea   +19 more
wiley   +1 more source

Aligning clinical care with consumer priorities: an adult cystic fibrosis centre experience of co‐designing a model of care

open access: yesInternal Medicine Journal, EarlyView.
Abstract Cystic fibrosis (CF) is a multi‐system genetic condition, and CF modulator therapies have transformed health outcomes promising improved longevity. Our aim was to co‐design and implement a nested endocrine and metabolic model of care called CF Endocrine for adults with CF that aligned with consumer and healthcare provider priorities and ...
Shanal Kumar   +3 more
wiley   +1 more source

Comparative histological analysis of vertebrates reveals Triassic climate variability across southern Pangea

open access: yesJournal of Anatomy, EarlyView.
Bone tissues of Triassic taxa reveal life history signals consistent with climatic variation across southern Pangea, spanning present‐day Brazil, Argentina, Zimbabwe, and India. Slower growth patterns within the Zimbabwean assemblage suggest a comparatively more arid intracontinental environment than those closer to the coast. Artwork by Andrey Atuchin.
Valerie Trinidad   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy