Results 81 to 90 of about 336,052 (300)

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

TIBIAL TUBERCLE FRACTURES IN CHILDREN AND ADOLESCENTS

Orthopaedic Journal of Sports Medicine, 2019
Background: Tibial tubercle fractures are uncommon sports related injuries. Only small series are reported in the literature. The purpose of this study is to report patient characteristics, fracture types, treatment methods, and clinical outcomes of ...
Daniel B. Haber MD, Frances Tepolt MD, Michael McClincy MD, Leslie Kalish Sc.D, Mininder S. Kocher MD MPH   +4 more
doaj   +1 more source

Ender nails in fractures of tibial shaft

, 1988
The treatment of tibial shaft fractures in polytraumatic patients are presented. From 1984 to 1987 we have treated 43 tibial shaft fractures with this method.
C. Ronzani, E. Bossi, R. Azzoni
core   +1 more source

PLATE FIXATION OF TIBIAL SHAFT FRACTURES

, 1971
1. One hundred and eighty-one fractures of the tibial shaft were treated by rigid fixation using conventional plates. 2. Comparison is made with series of fractures treated by the closed method. 3.
H. Nevile Burwell
core   +1 more source

Surgery of tibial pillar fractures [PDF]

, 2016
Lately there are more and more papers reporting on 1/3 lower leg trauma, the so-called tibial pillar fractures. During many years, it is considered that the most optimal method of treating fractures is conservative surgical treatment now becoming ...
GOIAN, V., TULBURE, V., SOLCANU, A., COŞPORMAC, I., BELOUS, A.   +4 more
core   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Percutaneous cement augmentation for the treatment of depression fractures of the tibial plateau [PDF]

, 2010
The management of insufficiency fractures of the tibial plateau in osteoporotic patients can be very challenging, since it is difficult to achieve a stable fixation, an essential condition for the patients' early mobilization.
A. K. Exadaktylos, L. M. Benneker, Heitkemper, S, Evangelopoulos, DS, Eggli, S, Haupt, U, D. S. Evangelopoulos, Benneker, LM, S. Eggli, Exadaktylos, AK, S. Heitkemper, U. Haupt, Exadaktylos AK, Benneker LM, Evangelopoulos DS, Haupt U, Heitkemper S, Eggli S   +17 more
core   +2 more sources

Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation

Advanced Science, EarlyView.
Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He   +10 more
wiley   +1 more source

Antibiofilm-coated intramedullary nailing for tibial and femoral diaphyseal fractures at high-risk infection: outcomes of 103 consecutive patients

Journal of Orthopaedics and Traumatology
Background Fracture-related infection (FRI) is a devastating complication of intramedullary nailing of tibial and femoral diaphyseal fractures. The present study evaluates the clinical efficacy of an antibacterially coated intramedullary nail in patients
Giovanni Vicenti, Filippo Migliorini, Michele Loiodice, Alessandro Scarpino, Priscilla D’attis, Luise Schäfer, Giulia Colasuonno, Giuseppe Solarino   +7 more
doaj   +1 more source

Management of segmental tibial fractures

, 2016
Segmental tibial fractures are uncommon injuries that occur in about 12.8% of tibial fractures. They are commonly caused by high-energy trauma. It is estimated that almost 50% of these fractures are open. They are often part of multiple injuries.
Motsitsi, NS
core   +1 more source