Results 41 to 50 of about 8,045 (245)

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

Magnetic resonance imaging findings in chronic anterior cruciate ligament‐deficient knees: A systematic review of meniscal, cartilage, tibial translation and ligamentous changes

Journal of Experimental Orthopaedics
Purpose The purpose of this study is to systematically review the literature for time‐dependent changes in knee anatomy and morphology on magnetic resonance imaging (MRI) in patients with chronically deficient anterior cruciate ligament (ACL) knees ...
Abel Davtyan, Ajay Shah, Quang Le, Ananya Pathak, Veronika Kolarska, Praveen Sritharan, Paul Marks, David Wasserstein   +7 more
doaj   +1 more source

Tibial Avulsion with Intra-Articular Entrapment of Medial Collateral Ligament with Posterior Cruciate Ligament Tear with Posterior Root Medial Meniscus Tear: A Case Report of an Unusual Injury Triad

JOURNAL OF ORTHOPAEDIC CASE REPORTS, 2021
Introduction: The medial collateral ligament (MCL) is the most commonly injured ligament of the knee joint; however, its displacement into the medial knee compartment is rare. Traumatic posterior root of medial meniscus (PRMM) tears are commonly found in high-grade injuries involving anterior cruciate ligament (ACL) or posterior cruciate ligament (PCL)
Shevate, Ishan, Nathani, Girish, Deshmukh, Ashwin, Kandari, Anirudh   +3 more
openaire   +2 more sources

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

A Case-Control Study Comparing Bone Bruising and Intra-articular Injuries in Patients Undergoing Anterior Cruciate Ligament Reconstruction With and Without Medial Collateral Ligament Tears

Orthopaedic Journal of Sports Medicine, 2016
Background: Concomitant injuries can occur in patients with combined anterior cruciate ligament (ACL) and medial collateral ligament (MCL) tears; however, no studies have compared these injuries in patients undergoing ACL reconstruction with an MCL tear ...
Melissa A. Kluczynski MS, John M. Marzo MD, Michael A. Rauh MD, Geoffrey A. Bernas MD, Leslie J. Bisson MD   +4 more
doaj   +1 more source

Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin, Ruiling Xu, Meagan J. Makarczyk, Jia‐Jun Liu, Silvia Liu, Matthew Z. Shi, Roberta Di Carlo, Michael F. Almeida, Alex Garris, Sarah Day, Rebekah Sanchez‐Hodge, Jonathan C. Schisler, Aleeza H. Zilberman, Noah G. Allen, Angela J. Kubik, Elizabeth A. Blaber, Arnold Z. Olali, Wanqing Xie, Douglas C. Wallace, Christopher E. Mason, Peter G. Alexander, Giuseppe Intini, Afshin Beheshti, Hang Lin   +23 more
wiley   +1 more source

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

Posterolateral tibial plateau impaction fractures in patients undergoing primary anterior cruciate ligament reconstruction—An MRI analysis of 556 cases

Journal of Experimental Orthopaedics
Purpose Posterolateral impaction fractures of the tibial plateau are known to be associated with anterior cruciate ligament (ACL) tears. These fractures are often related to high energy pivoting injuries, which is why the frequency of such injuries is of
Andreas Fuchs, Spartak Ovsepyan, Andreas Frodl, Tayfun Yilmaz, Markus Siegel, Matthias Krause, Thomas Stein, Hagen Schmal, Kaywan Izadpanah   +8 more
doaj   +1 more source

Clinical Outcomes and Patient Experiences With Celiprolol Therapy in Vascular Ehlers–Danlos Syndrome: The First Non‐European Cohort

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Vascular Ehlers–Danlos syndrome (vEDS) is a hereditary connective tissue disorder caused by heterozygous pathogenic variants in COL3A1. European studies have shown that celiprolol may reduce the risk of life‐threatening vascular events, but outcomes in non‐European populations and the therapy's psychological impact remain unclear. We conducted
Megumi Furuhata‐Yoshimura, Tomomi Yamaguchi, Tomoki Kosho   +2 more
wiley   +1 more source

Healing Integrity Determines Meniscal Extrusion After Isolated Medial Meniscus Posterior Root Repair in Knees With No Lower Limb Malalignment

Arthroscopy, EarlyView.
Purpose To investigate changes in meniscal extrusion and meniscal healing status following root repair, and the relationship between meniscal extrusion and healing conditions. Methods Patients who underwent isolated root repair between 2019 and 2023 and consented to undergo second‐look arthroscopy to evaluate their healing condition (1 year ...
Jin Seong Kim, Ui Jae Hwang, Chang Woo Woo, Choong Hyeok Choi, Kyu Sung Chung   +4 more
wiley   +1 more source