Results 211 to 220 of about 878,658 (384)

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang   +18 more
wiley   +1 more source

Hypoxia Exacerbates Periapical Periodontitis‐Associated Pathological Bone Loss via the Hypoxia‐Inducible Factor‐2α‐Calmodulin‐Dependent Protein Kinase IV Axis

open access: yesCell Proliferation, EarlyView.
Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao   +11 more
wiley   +1 more source

Acute neurologic presentation of a 2‐year‐old standardbred colt with multicentric diffuse large B cell lymphoma

open access: yesEquine Veterinary Education, EarlyView.
Summary Lymphoma in horses is uncommon and rarely diagnosed as a cause of ataxia. This case report describes a 2‐year‐old Standardbred cryptorchid colt who presented with acute onset of grade 3–4/5 spinal ataxia in all four limbs, with the hindlimbs more severely affected than forelimbs and severe proprioceptive deficits.
K. MacMillan   +3 more
wiley   +1 more source

Computed tomography identifies the proximodorsomedial subchondral bone of equine central tarsal bones as a predilection site for sclerosis, demineralisation and associated fractures

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background The distribution pattern of central tarsal bone (CTB) changes has not been described, except for slab‐ and dorsomedial–plantarolateral fractures. Objectives To describe CTB changes in CT and document their distribution and associations. Study Design Retrospective case series.
Sandra Campana   +3 more
wiley   +1 more source

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