Results 61 to 70 of about 41,299 (296)

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Phenol nerve block for ankle plantar flexor and invertor spasticity in upper motor neuron lesions: A case series

The Journal of the International Society of Physical and Rehabilitation Medicine, 2018
Aim: The study aims to evaluate the effectiveness of tibial nerve block with phenol on ankle plantarflexion and inversion spasticity caused by the upper motor neuron lesions.
Fahim Anwar, Harry Mee, Shruthika Ramanathan   +2 more
doaj   +1 more source

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

The normal value and influencing factors of shear wave elastography in healthy tibial nerves: A cross‐sectional study

Health Science Reports, 2023
Background and Aims Shear wave elastography is a potential method for evaluating peripheral neuropathy, but lacking reference values. The aim of this study was to measure tibial nerve stiffness in healthy individuals using shear wave elastography and to ...
Shiyao Shang, Wenxiao Yan, Yuping Guo, Hantao Guo, Rumin Chen, Shuzhen Cong, Chunwang Huang   +6 more
doaj   +1 more source

Electrophysiological characterization of activation state-dependent Cav2 channel antagonist TROX-1 in spinal nerve injured rats.

, 2015
Prialt, a synthetic version of Cav2.2 antagonist ω-conotoxin MVIIA derived from Conus magus, is the first clinically approved voltage-gated calcium channel blocker for refractory chronic pain.
Schiene, K., Damann, N., Damann, N, Rutten, K., Wigge, S., Schiene, K, Christoph, T., Schunk, S., Valdor, M, Valdor, M., Rutten, K, Schunk, S, Patel, R, Dickenson, A.H., Christoph, T, Wigge, S, Patel, R., Dickenson, AH   +17 more
core   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Correlation of Below-Knee Peripheral Artery Disease Stenosis with Nerve Conduction Velocity in Patients with Type 2 Diabetes Mellitus Peripheral Neuropathy

Jurnal Penyakit Dalam Indonesia
Introduction. One consequence of DM is the emergence of peripheral artery disease (PAD) and diabetic peripheral neuropathy (DPN). Diabetic peripheral neuropathy is a complication of diabetes that presents signs and symptoms of motor and sensory ...
Akbarbudhi Antono, Dono Antono, Birry Karim, Manfaluthy Hakim, Kuntjoro Harimurti, Dyah Purnamasari Sulistianingsih, Eka Ginanjar, Erni Juwita Nelwan, Pringgodigdo Nugroho   +8 more
doaj   +1 more source

Biofeedback pelvic floor muscle training and posterior tibial nerve electrostimulation for treatment of faecal incontinence: monotherapy versus combined therapy: a prospective randomized trial

Bulletin of the National Research Centre, 2022
Background Faecal incontinence is a common anorectal medical trouble among adult population. The aim was to compare the efficacy of biofeedback pelvic floor muscle training versus posterior tibial nerve electrical stimulation versus combination of both ...
Mervat Sheta Elsawy, Emmanuel Kamal Aziz Saba   +1 more
doaj   +1 more source

Terapia por diodo emissor de luz promove antihipersensibilidade, mas falha em acelerar regeneração nervosa após lesão do nervo ciático em camundongos [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2011Estudos recentes demonstraram que a terapia por diodo emissor de luz (LEDT, do inglês, light ...
Cidral Filho, Francisco José
core  

Biodegradable Zn‐Based Implants: Progress, Challenges, and Pathways toward Clinical Translation

Advanced Science, EarlyView.
Exploring biodegradable Zn‐based implants offers a promising pathway to next‐generation biomedical devices with balanced degradation and biocompatibility. A comprehensive overview of biodegradable Zn‐based implants, covering their biological significance, material design principles, and advanced engineering strategies is provided.
Panfeng Zhao, Zhengquan Wang, Hui Yang, Xiyuan Zhang, Hanyuan Liu, Xiaotong Lu, Xiaocheng Li, Yanyan Liu, Xi Zhao, Wenhao Zhou, Yufeng Zheng   +10 more
wiley   +1 more source