Results 101 to 110 of about 21,626 (283)

Osteocyte-Driven Downregulation of Snail Restrains Effects of Drd2 Inhibitors on Mammary Tumor Cells [PDF]

, 2018
While bone is a frequent target of breast cancer-associated metastasis, little is known about the effects of tumor-bone interactions on the efficacy of tumor-suppressing agents.
Chen, Andy, Fan, Yao, Jalali, Aydin, Li, Bai-Yan, Liu, Shengzhi, Minami, Kazumasa, Nakshatri, Harikrishna, Ogawa, Kazuhiko, Yokota, Hiroki   +8 more
core   +1 more source

cDC1 Subtype‐Specific In Vivo Targeting of Liposomes

Advanced Science, EarlyView.
Dendritic cells, particularly the cDC1 subtype, offer a promising target for drug delivery via liposomes due to their pivotal role in immune regulation, allowing for amplified therapeutic responses. Herein, we show an integration of physicochemical characterization and cell experiments to achieve effective in vivo cDC1 targeting through anti‐CLEC9A ...
Maximilian Schaaf, Michael Fichter, Lin Jian, Felicia Schön, Carina Jung, Paul Schneider, Kai Speth, Ana Mateos‐Maroto, Volker Mailänder, Kaloian Koynov, Svenja Morsbach, Katharina Landfester   +11 more
wiley   +1 more source

Lubrication model of a knee prosthesis, with non newtonian fluid and porous rough material [PDF]

, 2009
Tibial component of knee prostheses, made of ultra high molecular weight polyethylene (UHMWPE), experiences a high degree of wear and may be expected to last twelve years on average.
Berli, Marcelo Eduardo, Campana, Diego Martin, Di Paolo, José, Ubal, Sebastian   +3 more
core  

ACL injuries identifiable for pre-participation imagiological analysis: Risk factors [PDF]

, 2014
Identification of pre-participation risk factors for noncontact anterior cruciate ligament (ACL) injuries has been attracting a great deal of interest in the sports medicine and traumatology communities.
A Alizadeh, A Hemmerich, AD Georgoulis, AG Tsai, C Jardin, CC Chadwick, CL Highgenboten, DM Daniel, EA Arendt, G Selvik, GD Myer, H Balasch, H Dejour, H Jonsson, H Pereira, H Robert, HC Smith, HC Smith, HO Mayr, HS Park, HU Staubli, J Espregueira-Mendes, J Hashemi, J Isberg, J Kvist, J Menetrey, JF Benvenuti, JH Lubowitz, JH Oliver, JW Katz, JW Myrer, KM Sutton, L Stijak, L Stijak, LJ Bisson, LY Griffin, M Citak, M Miljko, M Prins, M Terauchi, MF Owings, MJ Feucht, MS Khan, MS Schulz, O Al-Saeed, OG Sorensen, P Boyer, P Sward, R Hudek, RA Simon, RJ Boniface, S Tashman, S Vyas, SC Wordeman, SLY Woo, TM Jung, TP Branch, TP Branch, V Musahl, Y Hoshino   +59 more
core   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Early Radial Extracorporeal Shockwave Stimulation on Proximal Tibial Circular Osteotomy Site Enhanced Heterotopic Skin Wound Healing via Small Extracellular Vesicles

Advanced Science, EarlyView.
A schematic diagram of the mechanism where small extracellular vesicles mediate the enhancement of heterotopic wound healing by radial extracorporeal shockwave stimulation at a proximal tibial osteotomy site. ABSTRACT Wound healing represents a complex biological process necessitating innovative therapeutic approaches, particularly for chronic wounds ...
Xiaoping Xie, Songqi Bi, Bang Su, Rongqi Zhou, Xudong Li, Zhixing Yan, Xiaoyang Zhou, Fanxu Wang, Tiecheng Yu   +8 more
wiley   +1 more source

Anterior Closing-Wedge Osteotomy for Posterior Slope Correction With Tibial Tubercle Preservation

Arthroscopy Techniques, 2019
An excessive posterior tibial slope has been identified as a potential risk factor for anterior cruciate ligament tears. Anterior closing-wedge osteotomy decreases the posterior slope and can eliminate this risk factor in patients with recurrent ...
Carlos Mesquita Queiros, M.D., Felipe Galvao Abreu, M.D., Joao Luis Moura, M.D., Guilherme Venturi de Abreu, M.D., Thais Dutra Vieira, M.D., Lionel Helfer, M.D., Bertrand Sonnery-Cottet, M.D.   +6 more
doaj   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Proximal tibial anatomical axis and anterior tibial cortex‐based measurements of posterior tibial slope on lateral radiographs differ least from actual posterior tibial slope—A biomechanical study

Journal of Experimental Orthopaedics
AbstractPurposeTo compare different measurement techniques of the posterior tibial slope (PTS) on lateral radiographs with the actual in situ PTS and evaluate the effect of tibial malrotation and image section length.MethodsActual PTS was measured on eight fresh‐frozen tibiae using a portable 6‐axis measuring arm with an accuracy of ±0.01°.
Christian Peez, Caroline Waider, Adrian Deichsel, Thorben Briese, Lucas K. Palma Kries, Elmar Herbst, Michael J. Raschke, Christoph Kittl   +7 more
openaire   +3 more sources

Substituent‐Based Modulation of Self‐Assembly and Immunogenicity of Amphipathic Peptides

Advanced Science, EarlyView.
This study systematically investigates how positional and subtle changes, such as substituents on the phenyl ring attached to short amphipathic peptides, influence their self‐assembly, fibril morphology, and immunogenic responses. ABSTRACT Self‐assembled peptide‐based biomaterials provide versatile platforms for biomedical uses, featuring customizable ...
Anirban Das, Ushasi Pramanik, Elise M. Brown, Chih‐Yun Liu, Huan Gong, Jonathan Fascetti, Mark Gibson, Samuel Stealey, Silviya P. Zustiak, Cory Berkland, Piyoosh Sharma, Meredith E. Jackrel, Mark A. White, Jai S. Rudra   +13 more
wiley   +1 more source