Results 71 to 80 of about 21,626 (283)

Therapeutic ultrasound as an aid in tibial fracture management in a dog [PDF]

, 2017
A six-year-old, male, neutered Bernese mountain dog was presented with acute left hind limb lameness. Based on the symptoms, orthopedic examination and radiographic evaluation, a cranial cruciate ligament rupture was diagnosed.
de Bakker, Evelien, Heremans, Jana, Samoy, Yves, Van Ryssen, Bernadette   +3 more
core   +1 more source

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, EarlyView.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Influence of tibial slope on extension and flexion gaps in total knee arthroplasty: increasing the tibial slope affects both gaps [PDF]

International Orthopaedics, 2014
Increasing the tibial slope is often performed if the flexion gap is narrower than the extension gap. The main hypothesis of this study is that increasing the tibial slope coincidentally enlarges the extension gap.Twenty formalin-fixed cadaveric knees were obtained for study.
Nowakowski, Andrej M., Kamphausen, Marcus, Pagenstert, Geert, Valderrabano, Victor, Müller-Gerbl, Magdalena   +4 more
openaire   +4 more sources

Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang, Jianbo Huang, Shuwei Zhang, Sujiao Cao, Fangxue Du, Liqiang Zhou, Li Qiu, Yuanjiao Tang   +7 more
wiley   +1 more source

Single-Stage Primary Anterior Cruciate Ligament Reconstruction With Slope-Reducing Anterior Closing-Wedge Proximal Tibial Osteotomy and a Lateral Extra-Articular Tenodesis

Arthroscopy Techniques
Anterior cruciate ligament (ACL) tears with known risk factors for anterior cruciate ligament reconstruction (ACLR) graft failure, such as elevated posterior tibial slope ≥12°, require a comprehensive treatment approach.
Evan P. Shoemaker, B.A., Luke V. Tollefson, B.S., Dustin R. Lee, M.D., Matthew T. Rasmussen, M.D., Robert F. LaPrade, M.D., Ph.D.   +4 more
doaj   +1 more source

A real 3D measurement technique for the tibial slope: differentiation between different articular surfaces and comparison to radiographic slope measurement

BMC Musculoskeletal Disorders, 2020
Background The tibial slope plays an important role in knee surgery. However, standard radiographic measurement techniques have a low reproducibility and do not allow differentiation between medial and lateral articular surfaces.
Armando Hoch, Lukas Jud, Tabitha Roth, Lazaros Vlachopoulos, Philipp Fürnstahl, Sandro F. Fucentese   +5 more
doaj   +1 more source

Nonlinear Elastic Material Property Estimation of Lower Extremity Residual Limb Tissues [PDF]

, 2003
The interface stresses between the residual limb and prosthetic socket have been studied to investigate prosthetic fit. Finite-element models of the residual limb-prosthetic socket interface facilitate investigation of the mechanical interface and may ...
Silver-Thorn, M. Barbara, Tönük, Ergin   +1 more
core   +2 more sources

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Factors influencing the posterior tibial slope after medial opening-wedge high tibial osteotomy. [PDF]

Front Bioeng Biotechnol
IntroductionMedial Opening-wedge High Tibial Osteotomy (HTO) is an effective treatment for medial compartment osteoarthritis and knee varus in relatively young and active patients. While it can effectively correct lower limb alignment in the coronal plane, it may also affect the posterior tibial slope (PTS) in the sagittal plane.
Li J, Yang Q, Zhang M, Yao J, Liu B, Luan Y, Chen Y, Fang C, Cheng CK.   +8 more
europepmc   +4 more sources