Results 81 to 90 of about 21,626 (283)

The effect of advanced glycation endproduct accumulation on bone [PDF]

, 2017
Diabetes is associated with increased fracture risk, which leads to increased morbidity and eventual mortality with a substantial financial burden.
Van Vliet, Miranda
core  

Comparable Maintenance of Tibial Slope in Two High Tibial Osteotomy Techniques

Orthopaedic Journal of Sports Medicine, 2013
Objectives: High tibial osteotomies (HTO) are commonly performed to correct coronal malalignment in young, active patients who have concomitant cartilage lesions and/or cruciate ligament insufficiency. An unintended change of native tibial slope can negatively affect both the strain on reconstructed cruciate ligaments and the contact forces on ...
Hamilton, Stephen Christopher, Bennett, Grant Whitby, Bush, Curtis Anderson, Wyland, Douglas J.   +3 more
openaire   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Anterior Open-Wedge Osteotomy to Correct Sagittal and Coronal Malalignment in a Case of Failed High Tibial Osteotomy and Failed Posterior Cruciate Ligament Reconstruction

Arthroscopy Techniques
Anterior open-wedge high tibial osteotomy of the proximal tibia is a reliable surgical procedure to treat genu recurvatum secondary to decreased posterior tibial slope.
K. Raghuveer Reddy, M.S., D.N.B., N. Somasekhara Reddy, M.S., M.Ch., N. Prakash, M.S.   +2 more
doaj   +1 more source

Redefining Dendritic Cell Vaccines: Synergistically Co‐priming DC and B Cells With Nanoparticles Loading Whole Cell Antigens Maximizes the Efficacy of DC Vaccines

Advanced Science, EarlyView.
Dendritic cells (DC) vaccine is an important type of vaccines. However, the limited efficacy of DC vaccines hinders their widely application. This study redefines DC vaccines and provides a new DC‐BC vaccine that have much better therapeutic efficacy.
Xiangxiang Xu, Xianlan Chen, Jin Wang, Yuhan Liu, Sidra Mustafa, Lu Diao, Rongrong Zhao, Haiyang Chi, Kang Hu, Jiashan Zhu, Jun Zhao, Mi Liu   +11 more
wiley   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Evaluation of the accuracy of a patient-specific instrumentation [PDF]

, 2017
Patient-specific instruments (PSI) has been introduced with the aim to reduce the overall costs of the implants, minimizing the size and number of instruments required, and also reducing surgery time.
Conteduca, Fabio, Ferretti, Andrea, Guzzini, Matteo, Iorio, Raffaele, Mazza, Daniele, Redler, Andrea   +5 more
core   +1 more source

ASSESSMENT OF TIBIAL SLOPE ANGLE AND PATELLAR HEIGHT AFTER MEDIAL-OPENING TIBIAL OSTEOTOMY

Revista Brasileira de Ortopedia (English Edition), 2012
To measure the variation in posterior tibial slope angle and patellar height in patients who underwent proximal tibial valgus-producing osteotomy using the medial-opening wedge technique.Anteroposterior panoramic radiographs of the lower limbs and lateral radiographs of the knee obtained before and after tibial valgus-producing osteotomy on 46 patients
de Paula Mozella, Alan, Vieira Costa, Marcos Areias, de Araujo Barros Cobra, Hugo Alexandre   +2 more
openaire   +2 more sources

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Quantifying the effect of hinge axis orientation on the posterior tibial slope angle during medial opening wedge high tibial osteotomy

Journal of Cartilage & Joint Preservation
Introduction: Research has suggested that rotating a medial open wedge high tibial osteotomy hinge axis internally or externally can change the posterior tibial slope and may create abnormal loading patterns through the tibia.
Timothy A. Burkhart, Victor A. Carranza, Thiago Vivacqua, Alan Getgood, Ryan Willing   +4 more
doaj   +1 more source