Advanced Science, EarlyView.This study provides evidence that anesthesia/surgery can induce the BBB breakdown and promote the release of hepatogenous C3 protein into the blood. This surgical dual factors ultimately drove C3 to cross the damaged BBB and selectively colocalize with C3aR in the hippocampus, which results in structural and functional injury of synapse, C3aR‐mediated ...
Qianqian Wu +17 more
wiley +1 more source
Premonitory Urges and Their Link With Tic Severity in Children and Adolescents With Tic Disorders
Frontiers in Psychiatry, 2019 Tics wax and wane regarding their severity, while their expression is affected by non-motor sensory or cognitive elements that are mostly known as “premonitory urges.” Since premonitory urges are often used in non-pharmacological interventions to ...
Maria Kyriazi +5 more
doaj +1 more source
Classification of tic disorders based on functional MRI by machine learning: a study protocol
BMJ Open, 2022 Introduction Tic disorder (TD) is a common neurodevelopmental disorder in children, and it can be categorised into three subtypes: provisional tic disorder (PTD), chronic motor or vocal TD (CMT or CVT), and Tourette syndrome (TS).
Ying Li +6 more
doaj +1 more source
A Robust Serum Proteomic Signature of the E2 Allele of Apolipoprotein E
Advanced Science, EarlyView.This study expands a serum protein signature of the e2 allele of APOE using multiple proteomic platforms and UK Biobank replication. The signature supports the role of APOE in lipid regulation through apolipoproteins and inflammation and includes, among others, neutrophil secreted granule proteins CAMP, CTSG, DEFA3, and MPO that point to inhibition of ...
Paola Sebastiani +20 more
wiley +1 more source
Tourette syndrome research highlights from 2016 [version 1; referees: 3 approved, 1 approved with reservations] [PDF]
, 2017 This article presents highlights chosen from research that appeared during 2016 on Tourette syndrome and other tic disorders.
Black, Kevin J
core +3 more sources
Advanced Science, EarlyView.Here, the study shows for the first time that Forsythoside E (FE) can promote PKM2 tetramerization by binding to its K311 site. Furthermore, it induces metabolic reprogramming of macrophages and inhibits NLRP3 expression. Finally, it can alleviate sepsis‐induced liver injury by promoting M2 anti‐inflammatory polarization.
Bingxin Wu +8 more
wiley +1 more source
Differentiating tics from functional (psychogenic) movements with electrophysiological tools
Clinical Neurophysiology Practice, 2019 Objective: We report on two patients that presented to our clinic with the differential diagnosis of functional movement disorder vs tic disorder. Case reports: The first patient is a 23-year-old woman with a 3-year history of repetitive involuntary neck
Felipe Vial +2 more
doaj +1 more source
Hair cortisol-a stress marker in children and adolescents with chronic tic disorders? A large European cross-sectional study [PDF]
, 2021 Judith Buse +50 more
openalex +1 more source
An Engineered Solidified Peptide Hemocyte Sponge as Nanomotor Storage to Combat Bacterial Colitis
Advanced Science, EarlyView.Peptides immobilized via nickel coordination can stabilize the framework structure. Following coating with red blood cell membranes, these constructs are capable of continuously sequestering endotoxins and mitigating colonic pathogenic damage by alleviating bacterial‐induced ferroptosis.
Yuxin Fang +8 more
wiley +1 more source
Psychosocial stress in children with Tourette syndrome and chronic tic disorder
Pediatrics and NeonatologyBackground: This study aimed to understand the longitudinal relationship between psychosocial stress with tic exacerbation in children with Tourette syndrome (TS) and chronic tic disorder. Methods: Consecutive ratings of tic severity as well as child and
Chiew Yin Tan +8 more
doaj +1 more source