Results 51 to 60 of about 2,440,906 (285)

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

Are other tick-borne infections overlooked in patients investigated for Lyme neuroborreliosis? : A large retrospective study from South-eastern Sweden

, 2021
In Europe, the hard tick Ixodes ricinus is considered the most important vector of human zoonotic diseases. Human pathogenic agents spread by I. ricinus in Sweden include Borrelia burgdorferi sensu lato (s.l.), Anaplasma phagocytophilum, Rickettsia ...
Gyllemark, Paula, Lindgren, Per-Eric, Jonsson Henningsson, Anna,, Wilhelmsson, Peter, Hovius, Joppe W.,, Lindgren, Per-Eric,, Wilhelmsson, Peter,, Hoornstra, Dieuwertje,, Elm, Camilla,, Elm, Camilla, Johansson, Marcus, Gyllemark, Paula,, Johansson, Marcus,, Sjöwall, Johanna,, Hoornstra, Dieuwertje, Tjernberg, Ivar,, Tjernberg, Ivar, Jonsson Henningsson, Anna, Sjöwall, Johanna, Hovius, Joppe W., Per-Eric Lindgren, Johanna Sjöwall, Paula Gyllemark, Ivar Tjernberg, Peter Wilhelmsson, Camilla Elm, Marcus Johansson, Joppe W. Hovius, Dieuwertje Hoornstra, Anna J. Henningsson   +29 more
core   +1 more source

Sticker Valence Governs Chain Collapse and Liquid‐Liquid Phase Separation in Peptide‐Inspired Associative Polymers

Advanced Science, EarlyView.
Peptide‐inspired associative polymers with arginine‐like guanidinium stickers and lysine‐like ammonium spacers undergo chain collapse and liquid‐liquid phase separation induced by reversible sticker associations. Sticker valence and tunable association strength jointly control the phase behavior, chain conformation, and interfacial cohesion of these ...
Seung‐Hwan Oh, Jinhoon Lee, Seunghyun Lee, Raehyun Jung, Sangyeop Lee, Su‐Mi Hur, Dong Woog Lee, Soo‐Hyung Choi   +7 more
wiley   +1 more source

Redox Imbalance and Its Metabolic Consequences in Tick-Borne Diseases

Frontiers in Cellular and Infection Microbiology, 2022
One of the growing global health problems are vector-borne diseases, including tick-borne diseases. The most common tick-borne diseases include Lyme disease, tick-borne encephalitis, human granulocytic anaplasmosis, and babesiosis.
Monika Groth, Elżbieta Skrzydlewska, Marta Dobrzyńska, Sławomir Pancewicz, Anna Moniuszko-Malinowska   +4 more
doaj   +1 more source

A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand

Advanced Science, EarlyView.
Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin, Kang Duan, Rui Wan, Tao Jiang, Jinzhe Wei, Miao Sun, Mariia A. Skryl'nikova, Maxim A. Gureev, Zhi‐Min Zhang, Zhang Zhang, Ke Ding, Nan Ma, Tongzheng Liu, Yi Tan, Zhengqiu Li   +14 more
wiley   +1 more source

Ticks and Tick-Borne Diseases of Utah [PDF]

, 2023
This fact sheet describes ticks and tick-borne diseases in Utah. It includes a description of ticks, their life cycle, habitat, feeding, and reproduction.
Richardson, Kate V., Ramirez, Ricardo, Davis, Ryan   +2 more
core   +1 more source

Co-infection of tick-borne bacterial pathogens in ticks in Inner Mongolia, China.

PLoS Neglected Tropical Diseases, 2023
Tick-borne infectious diseases pose a serious health threat in certain regions of the world. Emerging infectious diseases caused by novel tick-borne pathogens have been reported that are causing particular concern.
Dan Liu, Wulantuya, Hongxia Fan, Xiaona Li, Fangchao Li, Ting Gao, Xuhong Yin, Zitong Zhang, Minzhi Cao, Hiroki Kawabata, Kozue Sato, Norio Ohashi, Shuji Ando, Gaowa   +13 more
doaj   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Cloning, and Molecular Characterization of Polymorphic Iranian Isolate Theileria annulata Surface Protein (Tasp)

Iranian Journal of Parasitology, 2012
Background: Because of the strong immunologic responses of surface protein TaSp in Theileria annu­lata infected host, we tried to characterize this protein in a T. annulata isolate from Iran. Methods: The RNA prepared from T. annulata infected cells was
N Sadr-Shirazi, P Shayan, B Eckert, E Ebrahimzadeh, N Amininia   +4 more
doaj  

Replication enhancer elements within the open reading frame of tick-borne encephalitis virus and their evolution within the Flavivirus genus [PDF]

, 2011
We provide experimental evidence of a replication enhancer element (REE) within the capsid gene of tick-borne encephalitis virus (TBEV, genus Flavivirus).
I. M. Jones, Gould, EA, Tuplin, Andrew, Gould, E. A., A. Buckley, E. A. Gould, A. Tuplin, Tuplin, A., Jones, I. M., Jones, I. M. (Ian M.), Buckley, A., Gould, E., T. S. Gritsun, Jones, IM, Gritsun, T. S., Tuplin, A, Evans, DJ, Evans, David J., Gritsun, TS, D. J. Evans, Evans, D. J., Buckley, A, Evans, D. J.; id_orcid   +22 more
core   +1 more source