Results 51 to 60 of about 1,293,795 (280)

m5C Reader ALYREF Promotes the Progression of Endometrial Cancer by Activating the XRCC6‐Mediated Wnt/β‐catenin Signaling Pathway

Advanced Science, EarlyView.
This study identifies ALYREF as an oncogenic m5C reader in endometrial cancer. ALYREF recognizes NSUN2‐mediated m5C modification on XRCC6 mRNA to enhance transcript stability and increase XRCC6 expression. Elevated XRCC6 activates Wnt/β‐catenin signaling, resulting in accelerated tumor cell proliferation, migration, invasion, and xenograft tumor growth.
Linlin Hao, Jian Zhang, Qi Qian, Min Jiang, Yu Liu, Yan Geng, Nan Cui, Qi Guo, Jie Guo   +8 more
wiley   +1 more source

Growth of Cowdria ruminantium, the causative agent of heartwater, in a tick cell line [PDF]

, 2000
The tick-borne rickettsia Cowdria ruminantium has been propagated continuously for over 500 days in the Ixodes scapularis tick cell line IDE8 by using the Gardel isolate from bovine endothelial cells as an inoculum.
Sumption, Keith J, Bell-Sakyi, Lesley, Paxton, Edith, Munderloh, Ulrike G   +3 more
core  

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source

Chemical Inhibition of Pyocyanin Biosynthesis Attenuates Virulence of Pseudomonas aeruginosa

Angewandte Chemie, EarlyView.
Anti‐virulence strategies disarm pathogens rather than killing them directly. A β‐lactone reduces pyocyanin production without affecting growth. Chemical proteomics identified PqsC as the primary target via binding to Cys129. Crystallography revealed the binding mode, and SAR yielded a chloroacetamide inhibitor with improved enzymatic potency and anti ...
Wei Ding, Sebastian R. Borgert, Wulf Blankenfeldt, Stephan A. Sieber   +3 more
wiley   +2 more sources

Functional and Immunological Relevance of Anaplasma marginale Major Surface Protein 1a Sequence and Structural Analysis. [PDF]

, 2013
Bovine anaplasmosis is caused by cattle infection with the tick-borne bacterium, Anaplasma marginale. The major surface protein 1a (MSP1a) has been used as a genetic marker for identifying A.
Barbosa Ribeiro, Mucio Flavio, M. F., Ferrolho, Joana, Zweygarth, Erich, José de la Fuente (35632), Ribeiro, Mucio F. B., Valdés, J.J., Cabezas Cruz, Alejandro, Erich Zweygarth, Katherine M Kocan, Miray Tonk (420443), Rachel Kenneil, Cabezas-Cruz, A., Rachel Kenneil (420441), Anna E. Pohl (420444), Estrada-Peña, A., Miray Tonk, Agustín Estrada-Peña (52766), Ribeiro, M.F.B., Lygia M F Passos, Katarzyna Lis, de la Fuente, J., James J Valdés, Kocan, Katherine M., Zweygarth, E., de la Fuente, José, Mucio F. B. Ribeiro (420448), Alejandro Cabezas-Cruz, Libor Grubhoffer, Lygia M. F. Passos (420439), Estrada-Peña, Agustín, Agustín Estrada-Peña, Lis, K., Katherine M. Kocan (326058), Valdes, James J, Joana Ferrolho (420442), Kenneil, Rachel, Kocan, K.M., Passos, Lygia Maria Friche, James J. Valdés (409724), Passos, Lygia M. F., Erich Zweygarth (420446), Valdés, James J., Shkap, Varda, Pohl, Anna E., Varda Shkap, Pohl, A.E., Varda Shkap (420447), Libor Grubhoffer (420445), Grubhoffer, L., Lis, Katarzyna, Tonk, Miray, Katarzyna Lis (420440), Alejandro Cabezas-Cruz (420438), Cabezas-Cruz, Alejandro, Passos, Lygia, Tonk, M., Mucio F B Ribeiro, Kenneil, R., Anna E Pohl, Joana Ferrolho, Shkap, V., José de la Fuente, Ferrolho, J., Barbosa Ribeiro, Mucio Flavio, Grubhoffer, Libor, Passos, L.M.F., Shkap Varda, Lis Katarzyna, Kenneil Rachel, Tonk Miray, Barbosa Ribeiro, Mucio Flavio,, Zweygarth Erich, Ribeiro Mucio F. B., Pohl Anna E., Kocan Katherine M., Passos Lygia M. F., Fuente, José de la, Ferrolho Joana, Cabezas-Cruz Alejandro, Valdés James J., Grubhoffer Libor, Estrada-Peña Agustín, de la Fuente José   +82 more
core   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Chemoenzymatic Synthesis of 6‐Sulfo Sialyl Lewisx Containing Glycans to Probe the Receptor Specificity of MERS Coronavirus

Angewandte Chemie, EarlyView.
A chemoenzymatic methodology is described that provided a panel of 6‐sulfo sialyl Lewisx‐containing glycans that were probed for receptor specificity of MERS‐CoV. Although the fucoside of 6‐sulfo‐SLex does not directly interact with the spike, it pre‐organizes the molecule into a conformation to allow a salt bridge between the sulfate and the ...
Yunfei Wu, Anne L.M. Kimpel, Jacobus P. van Trijp, Elif Uslu, Gaёl M. Vos, Luca Unione, Robert P. de Vries, Geert‐Jan Boons   +7 more
wiley   +2 more sources

Socio-Demographic and Eco-Epidemiological Parameters of Tick-Borne Infections Morbidity in Baikal Region

Проблемы особо опасных инфекций
The aim of the work was to compare the main socio-demographic and eco-epidemiological parameters of tick-borne viral encephalitis, tick-borne borrelioses and tick-borne rickettsiosis.Materials and methods.
O. V. Mel’nikova, N. A. Bykova, N. V. Ustinova, E. I. Andaev   +3 more
doaj   +1 more source

Luciferase activity changes during the acute period of tick-borne mixed infection in children

Бюллетень сибирской медицины, 2008
The research of clinical characteristics of different tick mixed infections etiological variants in children — tick-borne encephalitis, ixodid tick-borne borreliosis, granulocytic anaplasmosis and monocytic ehrlichiosis in human in Kemerovo region showed
O. S. Pinevich, T. V. Poponnikova, A. S. Sukhikh, S. F. Zinchuk, G. Yu. Galiyeva   +4 more
doaj   +1 more source

Schwere Frühsommermeningoencephalitis (FSME) sechs Jahre nach korrekter Impfung [PDF]

, 2009
A case of severe tick-borne encephalitis (TBE) 6 years after correct vaccination – could it have been prevented by a search for seroconversion after vaccination?
S Rüttimann, A Kind, Kind, A., Rüttimann, S.   +3 more
core   +1 more source