Results 51 to 60 of about 6,497 (187)

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

First cluster of relapsing fever compatible with louse-borne transmission in southern Saudi Arabia: An eight-case series from Najran

Journal of Infection and Public Health
Louse-borne relapsing fever (LBRF), caused by Borrelia recurrentis, is a neglected vector-borne infection associated with overcrowding, migration, and poor hygiene conditions. We describe eight spatiotemporally linked cases of Borrelia spp.
Mohammed Bazuqamah, Ali Bazqamah, Mohammad Moharram, Amira Soliman, Ghada Balah, Eslam Helal, Hend Masoud, Ali Garbo, Hadi Al Sulayyim   +8 more
doaj   +1 more source

Tick-Borne Diseases in Turkey: A Review Based on One Health Perspective. [PDF]

PLoS Neglected Tropical Diseases, 2016
The importance of tick-borne diseases is increasing all over the world, including Turkey. Global warming, environmental and ecological changes and the existence of suitable habitats increase the impact of ticks and result in frequent emergence or re ...
Abdullah Inci, Alparslan Yildirim, Onder Duzlu, Mehmet Doganay, Serap Aksoy   +4 more
doaj   +1 more source

Nanomedicine Meets Immunotherapy: Transforming Chimeric Antigen Receptor T Cell Treatment for Solid Tumors

Small Science, Volume 6, Issue 2, February 2026.
This review highlights recent advances in nanomedicine that enhance chimeric antigen receptor (CAR) T cell therapy against solid tumors. It discusses key barriers to CAR T cell efficacy and outlines nanotechnology‐based strategies to improve tumor targeting, remodel the immunosuppressive microenvironment, and integrate nanomaterials into CAR T cell ...
Stephen O’Rourke, Nuo Xu, Hongjun Wang, Hexin Chen   +3 more
wiley   +1 more source

Molecular Screening of Black Flies (Diptera: Simuliidae) for Vector‐Borne Zoonotic Pathogens, South Moravia, Czech Republic

Zoonoses and Public Health, Volume 73, Issue 1, Page 95-106, February 2026.
ABSTRACT Introduction Black flies (Simuliidae) are globally distributed blood‐feeding arthropods and vectors of viral, bacterial, and parasitic pathogens to many animal species, including humans. We investigated the occurrence of selected vector‐borne pathogens in black flies in South Moravia, Czech Republic, and evaluated their possible role in the ...
Silvie Šikutová, Kristína Mravcová, Jan Mendel, Oldřich Šebesta, Bohumil Sak, Nikola Holubová, Martin Kváč, Clifton McKee, Peter H. Adler, D. Otranto, Ivo Rudolf   +10 more
wiley   +1 more source

Comparative Analysis of Tick-Borne Relapsing Fever Spirochaetes from Ethiopia and Nigeria [PDF]

In recent decades, the reports of tick-borne relapsing fever (TBRF) spirochaetes and its tick vectors have been increasing in Africa. Soft ticks of the Ornithodoros genus are the predominant vector for these spirochaetes and are endemic in many regions ...
Bankole, Adefolake
core   +1 more source

Estimated seroprevalence of Ehrlichia canis in dogs in a remote community in the Northern Territory, Australia

Australian Veterinary Journal, Volume 104, Issue 1-2, Page 66-72, January-February 2026.
Background The emergence of Ehrlichia canis in northern Australia in 2020 has reshaped the landscape of tick‐borne diseases in dogs, particularly in rural and remote communities where the brown dog tick (Rhipicephalus linnaei) is endemic. Despite the rapid spread of ehrlichiosis and reported impacts on dog health, its prevalence remains poorly ...
E Shepherdson, K Doust, JH Hoopes, AD Barbosa, J McNeill   +4 more
wiley   +1 more source

Borrelia miyamotoi Disease in an Immunocompetent Patient, Western Europe

Emerging Infectious Diseases, 2018
Borrelia miyamotoi disease is a hard tick–borne relapsing fever illness that occurs across the temperate climate zone. Human B. miyamotoi disease in immunocompetent patients has been described in Russia, North America, and Japan. We describe a case of B.
Dieuwertje Hoornstra, Joris Koetsveld, Hein Sprong, Alexander E. Platonov, Joppe W. Hovius   +4 more
doaj   +1 more source

Molecular surveillance reveals a potential hotspot of tick-borne disease in Yakeshi City, Inner Mongolia

BMC Microbiology, 2023
A molecular surveillance of tick-borne diseases was performed in Hulunbuir City, Inner Mongolia. A total of 149 ticks including three species (Ixodes persulcatus, Haemaphysalis concinna, and Dermacentor silvarum) were collected.
Junhua Tian, Jing Liu, Hongqing Zhao, Xiaomin Chen, Xueqin Geng, Miao Lu, Kun Li   +6 more
doaj   +1 more source