Results 141 to 150 of about 1,267,255 (211)

Advances in CRISPR‐based detection technologies for severe fever with thrombocytopenia syndrome virus (Dabiebanda virus): A mini review

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review summarises the detection methods for severe fever with thrombocytopenia syndrome virus based on CRISPR platforms. (A) CRISPR with fluorescent reporter. (B) CRISPR with lateral flow test strip. (C) CRISPR with DNAzyme. (D) Digital CRISPR. (E) CRISPR with single micro‐ring resonator biosensor. (F) self‐amplifying signal amplification strategy
Junhu Wang, Changqiang Zhu, Jinzhao Chu, Yingqing Mao, Yixin Ge, Haiming Yi, Hongming Wang, Yuexi Li, Yong Qi   +8 more
wiley   +1 more source

All‐Oral PI3Kδ and HDAC Inhibition with Parsaclisib Plus Chidamide and Step‐Down Maintenance in Relapsed or Refractory Peripheral T‐Cell Lymphoma: A Phase Ib Trial

MedComm, Volume 7, Issue 10, October 2026.
ABSTRACT Single‐agent targeted therapies for relapsed or refractory peripheral T‐cell lymphoma (R/R peripheral T‐cell lymphoma [PTCL]) produce modest, short‐lived responses, underscoring the need for tolerable, chemotherapy‐free combinations. In an open‐label, single‐arm Phase Ib trial at two tertiary hospitals, we evaluated parsaclisib plus chidamide ...
Xufeng Luo, Zheng Yan, Wei Fang, Hanchi Duan, Qiuyu Zhang, Haiying Wang, Shuna Yao, Jiuyang Zhang, Yiping Jin, Wenyong Li, Xiaolu Teng, Lina Zhang, Lijie Liang, Quande Lin, Ping Wang, Haoran Si, Jinxin Miao, Wenping Zhou, Zhihua Yao, You‐Wen He, Qingxin Xia, Yanyan Liu   +21 more
wiley   +1 more source

Virus‐Mediated Self‐Assembly of Functional Cyclodextrins for Antiviral Inhibition

Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.
A sialic acid (SA)‐functionalized cyclodextrin (CD) self‐assembles on SARS‐CoV‐2 through ligand–receptor recognition, nucleating cooperative supramolecular polymer growth that blocks infection. The adaptive assembly requires both ligand binding and host–guest polymerization, remains active across variants, and can be tuned by coassembly, establishing ...
Pedro J. Hernando, Laora Boulo, Léonid Lavnevich, Elisa Teyssou, Stéphane Marot, Adélie Gothland, Jean‐Michel Guigner, Anne‐Geneviève Marcelin, Mickaël Ménand, Vincent Calvez, Matthieu Sollogoub   +10 more
wiley   +2 more sources

Can landscape management provide disease regulation services? A case study of Brazilian spotted fever incidence

Journal of Applied Ecology, Volume 63, Issue 10, October 2026.
Policy implications. Our results can help prioritize surveillance strategies and the implementation of preventive measures, particularly in areas where landscape structures cannot provide disease regulation services. Landscape management actions aimed at increasing the amount of forest areas in a more aggregated manner could help restore those ...
Nicolas Conserva, Paula Ribeiro Prist, Gabriela Farias Asmus, Niko Speybroeck, Leandro Reverberi‐Tambosi   +4 more
wiley   +1 more source

Assessing the Use of Oxford Nanopore Technologies Sequencing for Detection of Stable Wolbachia Bacterial Strain in Symbiosis in Wild Anopheles Mosquitoes From the WHO African Region

Environmental Microbiology, Volume 28, Issue 10, October 2026.
This study assesses Oxford Nanopore Technology sequencing to detect Wolbachia in Anopheles mosquitoes. To do this, samples were analysed using the ONT field sequencing kit and sequenced using a minION flow cell and the ONT 16S barcoding kit and Rapid barcoding kit sequenced using Flongle flow cells.
Laura Chatterley, Nicola Hull, Isabel Hughes, Seynabou Sougoufara, Owain Meek, Murat Ceyran, Vishaal Dhokiya, Janvier Bandibabone, Cyprian Adala, Elin Cunningham, Shehu Shagari Awandu, Helene Kaminski‐Nenkam, Antonio Nkondjio, Grant L. Hughes, Eva Heinz, Thomas Walker   +15 more
wiley   +1 more source

Ezh2 Inhibits the Differentiation of Short‐Lived Effector CD8+ T Cells and Promotes T Cell‐Dependent Antitumor Immunity

Cancer Science, Volume 117, Issue 10, Page 2644-2658, October 2026.
The antitumor immune response is attenuated in T cell‐specific Ezh2 knockout mice. ABSTRACT Appropriate regulation of the differentiation balance between effector CD8+ T cells and memory CD8+ T cells is crucial for an appropriate immune response. We previously reported that the tumor suppressor menin suppresses the differentiation of CD8+ T cells into ...
Kenji Takagi, Junpei Suzuki, Yuko Matsuoka, Makoto Kuwahara, Taro Oshikiri, Masakatsu Yamashita   +5 more
wiley   +1 more source

A scoping review of the acceptability, feasibility and effectiveness of opt‐out blood‐borne virus (BBV) testing in secondary healthcare settings, in the UK and similar settings, using APEASE criteria

HIV Medicine, Volume 27, Issue 10, Page 1558-1583, October 2026.
Abstract Background Earlier diagnosis of blood‐borne viruses (BBVs)—HIV, hepatitis B (HBV) and hepatitis C (HCV)—remains a significant public‐health focus. Opt‐out testing in secondary healthcare settings can improve early diagnosis and linkage to care as part of BBV transmission elimination targets.
Becky Metcalfe, Karen J. Maxwell, Kirsten Trayner, Max Wilkinson, Sharon Hutchinson, Claudia Estcourt, Alison J. Rodger   +6 more
wiley   +1 more source

Beyond the Kidney and Lung: Cutaneous and Mucosal Clues to Human Hantavirus Disease

International Journal of Dermatology, Volume 65, Issue 10, Page 2018-2027, October 2026.
Rodent exposure and aerosolized excreta can lead to hantavirus infection with systemic endothelial injury and capillary leak, resulting in thrombocytopenia and syndromes such as HPS/HCPS and HFRS/NE. Early dermatologic and mucosal findings, including flushing, conjunctival injection, petechiae/purpura, and mucosal bleeding, may provide important clues ...
Giuseppe Gallo, Pietro Quaglino, Simone Ribero   +2 more
wiley   +1 more source

Transcriptomic and Metabolomic Profiling Identifies a Core Gene–Metabolite Axis Driving African Swine Fever Virus Replication in the Soft Tick Ornithodoros lahorensis

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Transcriptomic and metabolomic profiling of Ornithodoros lahorensis during African swine fever virus (ASFV) infection reveals that ASFV rewires host purine/pyrimidine metabolism, lipid metabolism, and energy metabolism. A core gene‐metabolite regulatory axis consisting of 12 key genes and 8 signature metabolites is identified to support viral genome ...
Jin Luo, Kaifei Guo, Fangyu Xiao, Ruoqi Wang, Junhui Guo, Qiaoyun Ren, Shuaiyang Zhao, Muhammad Kashif Obaid, Guiquan Guan, Hong Yin   +9 more
wiley   +1 more source

Ticks Tick Borne Dis [PDF]

As part of a TickNET collaboration we evaluated the knowledge, attitudes, and behaviors related to tick-borne disease (TBD) prevention among persons living in endemic areas of Connecticut (CT) and Maryland (MD).

core   +2 more sources