Results 51 to 60 of about 1,267,255 (211)

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Novel variants of tick-borne encephalitis virus from patient and tick samples in Norway [PDF]

The annual number of tick-borne encephalitis (TBE) cases in Norway has increased dramatically from 1 case in 1998 to 113 in 2023. Characterization of TBE virus (TBEV) genomes from both clinical samples and tick vectors is necessary to understand disease ...
Skudal, Hilde Kristin, Andreassen, Åshild K., Pettersson, John H.-O., Vikse, Rose, Lindstedt, Heidi Elisabeth Heggen, Sydow, Anita Koskela von, Andreassen, Åshild Kristine, Asghar, Naveed, Soleng, Arnulf, Maharjan, Urusha, Fevang, Borre, Alfsnes, Kristian, Bjerkreim, Randi Haukaas, Johansen, Wenche, Basnet, Suyog, Fevang, Børre, Bjerkreim, Randi, Von Sydow, Anita Koskela, Johansson, Magnus   +18 more
core   +1 more source

Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma

Advanced Science, EarlyView.
Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Alexandra R. Paul, Alexandra Moreno Mitchell, Dean O'Neil, Yutong Luo, Khuloud T. Al‐Jamal   +4 more
wiley   +1 more source

Schwere Frühsommermeningoencephalitis (FSME) sechs Jahre nach korrekter Impfung [PDF]

, 2009
A case of severe tick-borne encephalitis (TBE) 6 years after correct vaccination – could it have been prevented by a search for seroconversion after vaccination?
S Rüttimann, A Kind, Kind, A., Rüttimann, S.   +3 more
core   +1 more source

Fatal Tick-Borne Encephalitis in Unvaccinated Traveler from the United States to Switzerland, 2022

Emerging Infectious Diseases
We report an unvaccinated traveler from the United States who contracted fulminant fatal tick-borne encephalitis while visiting Switzerland. Climate changes and international travel are intensifying tick exposure for unvaccinated persons. The increasing
Chiara Scotti, Gilbert Greub, Yannis Ahmad, Simon Burgermeister, Giovanni Di Liberto, Ekkehard Hewer, Paola Vassallo, Olivier Pantet   +7 more
doaj   +1 more source

Similarities and differences in the characteristics of the epidemical process tick-borne encephalitis and Lyme borreliosis

Журнал инфектологии, 2023
Objective: To identify common and distinctive characteristics of the epidemical process of tick-borne encephalitis and Lyme borreliosis on the example of the Republic of Karelia.Materials and methods.
L. V. Rubis, O. V. Ekimova, О. S. Safonova, V. Е. Chevskaya   +3 more
doaj   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

A New Tick-borne Encephalitis-like Virus Infecting New England Deer Ticks, Ixodes dammini

Emerging Infectious Diseases, 1997
To determine if eastern North American Ixodes dammini, like related ticks in Eurasia, maintain tick-borne encephalitis group viruses, we analyzed ticks collected from sites where the agent of Lyme disease is zoonotic.
Sam R. Telford, Philip M. Armstrong, Paula Katavolos, Ivo Foppa, A. Sonia Olmeda Garcia, Mark L. Wilson, Andrew Spielman   +6 more
doaj   +1 more source

Magnetoreceptor Promotes Hepatocellular Carcinoma Development and Blunts Sorafenib‐Induced Ferroptosis by Regulating Iron Homeostasis

Advanced Science, EarlyView.
Magnetoreceptor (MagR) regulates iron homeostasis and mitochondrial function in hepatocellular carcinoma (HCC) cells. Specifically, MagR deficiency suppresses tumor cell proliferation, migration, and invasion and enhances sorafenib‐induced ferroptosis through iron accumulation.
Tao Wang, Chenghua Song, Xin He, Mengzhou Wang, Wuming Liu, Xiaolin Wang, Yuanyuan Zhang, Jia Zhang, Lin Zhang, Dan Li, Yu Zhang, Zheng Wu, Yi Lyu, Rongqian Wu   +13 more
wiley   +1 more source

Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection

npj Vaccines, 2017
Tick-borne encephalitis: One vaccine protects against multiple flaviviruses Prior exposure to tick-borne encephalitis virus confers immunity to distinct, but genetically related, significant human pathogens.
Alexander J. McAuley, Bevan Sawatsky, Thomas Ksiazek, Maricela Torres, Miša Korva, Stanka Lotrič-Furlan, Tatjana Avšič-Županc, Veronika von Messling, Michael R. Holbrook, Alexander N. Freiberg, David W. C. Beasley, Dennis A. Bente   +11 more
doaj   +1 more source