Results 221 to 230 of about 474,242 (359)

Investigation of Genotypes of Borrelia burgdorferi in Ixodes scapularis Ticks Collected during Surveillance in Canada

, 2011
N. H. Ogden, Gabriele Margos, David M. Aanensen, Michael Drebot, Edward J. Feil, K. Hanincová, Ira Schwartz, Shaun Tyler, L. Robbin Lindsay   +8 more
openalex   +2 more sources

Metagenomic surveillance of tick-borne pathogens and microbiomes in Huntingdon County, Pennsylvania. [PDF]

One Health
Buonaccorsi A, McMullen BN, Builder B, Drummond K, Halteman S, See JC, Thomas E, Viands A, Worley S, Wright JR, Keeney J, Lamendella R.   +11 more
europepmc   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

An Evidence Based Rationale for Making Tick - borne Relapsing Fever a Nationally Notifiable Disease

, 2019
Kyle M Hatcher
openalex   +1 more source

Variety of Bacterial Pathogens in Ticks Removed from Humans, Northeastern China. [PDF]

Microorganisms
Su XL, Ye JL, Zhang MZ, Wang YF, Sun Y, Wu YF, Bian C, Yao NN, Zheng YC, Jiang JF, Zheng XM, Cao WC.   +11 more
europepmc   +1 more source

Affinity‐Based Protein Profiling Revealed that HIGD1A is a Direct Target Protein of Aristolochic Acids

Advanced Science, EarlyView.
Using an affinity‐based probe, this study reveals that aristolochic acid directly binds to HIGD1A with high affinity in the kidney. This binding disrupts the HIGD1A‐TFAM interaction, which in turn triggers TFAM degradation, cytosolic mitochondrial DNA release, and the activation of inflammatory pathways. Abstract Exposure to aristolochic acids (AA) via
Yin Gong, Shanshan Zhang, Anying Wei, Xiang Ji, Xiaodan Chong, Jinfeng Cen, Xuan Zhao, Zimeng Luo, Zhipeng Pei, Guanchao Mao, Xinkang Zhang, Mingxue Sun, Zhiguo Sun, Zifei Yin, Zhengrong Zou, Wen‐Qi Meng   +15 more
wiley   +1 more source

Diverse virome and potential pathogens in five tick species from metropolis surroundings of Beijing and Tianjin, China. [PDF]

NPJ Biofilms Microbiomes
Gao WY, Xia X, Wang TH, Liu YT, Wang J, Li YY, Xia LY, Jia N, Jiang JF, Sun Y, Cui XM, Ye RZ, Zhao L, Cao WC.   +13 more
europepmc   +1 more source

Alpinetin Nanoparticles Alleviate Optic Nerve Injury Induced by Acute Glaucoma via LRP1‐PPARγ Mediated Regulation of Microglial Lipid Metabolism

Advanced Science, EarlyView.
Microglial lipid metabolic dysfunction drives neurodegeneration in glaucoma. We found loss of LRP1 causes lipid accumulation and inflammation. We developed alpinetin‐loaded nanoparticles (AlpNPs) that bind LRP1, activate the PPARγ‐LXRα‐ABCA1 pathway to restore lipid homeostasis, promote an anti‐inflammatory phenotype, and protect retinal ganglion cells,
Miao Wei, Yujia Huo, Jingchang Yuan, Xiao Fan, Xiaochen Wang, Sisi Tan, Xi Gao, Ruotong Ouyang, Hong Li   +8 more
wiley   +1 more source

Molecular identification of <i>Borrelia</i> and <i>Rickettsia</i> in hard ticks infesting domestic and wild animals in Cameroon. [PDF]

Parasite Epidemiol Control
Paguem A, Kamtsap P, Manchang KT, Renz A, Schaper S, Dobler G, Rollins RE, Chitimia-Dobler L.   +7 more
europepmc   +1 more source

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
wiley   +1 more source