Results 221 to 230 of about 143,398 (260)

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

<i>In vitro</i> feeding of nymphal <i>Haemaphysalis longicornis</i> supports moulting to adults and maintains <i>Coxiella</i>-dominated microbiome across life stages. [PDF]

Curr Res Parasitol Vector Borne Dis
Ghafar A, Mustafa BE, Khan M, Gauci C, Beveridge I, Gasser RB, Nijhof AM, Jabbar A.   +7 more
europepmc   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Tick-borne encephalitis virus in <i>Dermacentor reticulatus</i> ticks, Poland. [PDF]

PeerJ
Reinbold-Wasson DD, Gandhi J, Li T, Kiratli OLZ, Richardson JB, Kugelman JR, Lapoint ZR, Bernota PJ, Hall GR, Fung CK, Friberg HL, Gromowski GD, McCracken MK, Kirkitadze G, Shubashishvili A, Chunashvili T, Collins ND, Musich TA, Hang J, Conte MA.   +19 more
europepmc   +1 more source

The Effect of Ligand Reactivity and Carrier Mechanics on Thiol‐Mediated Cellular Uptake for miRNA Nano‐Drugs

Advanced Science, EarlyView.
The effect of ligand reactivity and carrier mechanics on thiol‐mediated uptake was investigated at the single‐molecule/particle level. The interaction kinetics of LA and AspA with membrane thiols were quantified; AspA is more efficient due to the higher binding affinity, greater binding stability, and more double‐disulfide binding, as well as greater ...
Zhuang Zhang, Hui Wang, Hao Zhang, Zhenkuan Cao, Zehui Liu, Siying Li, Hongda Wang, Yuping Shan   +7 more
wiley   +1 more source

Coseropositivity to Tick-Borne Pathogens Among Patients Suspected to Have Lyme Disease.

JAMA Netw Open
Li Y, Tong CH, Givens TS, Boyce RM.
europepmc   +1 more source

Tick-borne bacterial pathogens in wildlife and their parasitizing ticks in Korea: A molecular epidemiological study. [PDF]

Parasites Hosts Dis
Lee YJ, Kim B, Hyun YS, Heo JW, Woo HM, Choi JW, Choi I, Kang YM, Rhee MH, Kwak D, Kim KT, Seo MG.   +11 more
europepmc   +1 more source

Sequential Patterning of Photoresponsive Hydrogels Directs Crypt Fission and Reveals the Role of Epithelial Curvature on Fission Symmetry

Advanced Science, EarlyView.
Deterministic crypt fission is achieved in intestinal organoids using photopatternable hydrogels with spatiotemporal control. Daughter‐crypt symmetry is shown to depend on parent‐crypt geometry and epithelial curvature, while myosin‐dependent mechanosensing links tissue shape to regenerative outcomes.
Delaney L. McNally, Kaustav Bera, Nolan R. Petrich, Alex Khang, Marilyne Coulombe, David Castillo‐Azofeifa, Ophir D. Klein, Peter J. Dempsey, Kristi S. Anseth   +8 more
wiley   +1 more source

Emerging Clinical Complications of Alpha-Gal Syndrome: A Scoping Review. [PDF]

Cureus
Vundamati VS, Patel SR, Patel R, Eriskin N, Tila-Cohen B, Friedrich CJ, Gupta A, Neupane R, Arango S, Kesselman MM.   +9 more
europepmc   +1 more source