Results 251 to 260 of about 469,795 (310)

Metagenomic evidence of viral secretion from tick salivary glands to saliva: implications for potential horizontal transmission

open access: gold
Jun Ni   +9 more
openalex   +1 more source

A Robust Synthesis of Fluorosurfactants with Tunable Functionalities via a Two‐Step Reaction

open access: yesAdvanced Science, EarlyView.
The fluorosurfactants are synthesized through a two‐step reaction, and demonstrated excellent performance in droplet microfluidics. In addition, they exhibited tunable functionalities at the droplet interface via hydrogen bonding and coordination interactions.
Jiyuan Yao   +10 more
wiley   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

open access: yesAdvanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang   +17 more
wiley   +1 more source

Quantifying the Single‐Cell Morphological Landscape of Cellular Transdifferentiation through Force Field Reconstruction

open access: yesAdvanced Science, EarlyView.
This study reconstructs the driving force field of fibroblast‐to‐neuron transdifferentiation from sparse single‐cell images by decomposing it into flux and time‐dependent potential gradient, extending the landscape‐flux framework to non‐steady‐state systems.
Chudan Yu   +3 more
wiley   +1 more source

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