Results 161 to 170 of about 48,508 (266)

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

Advanced Science, EarlyView.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen, Paili Lin, Yongfang Xia, Zhiqiang Liu, Zilu Cheng, Qingmei Zhu, Shiqi Wan, Xiaoyu Chen, Haiyan Bao, Renbo Qiao, Gechang Zhong, Ying Zhu, Shi Liu   +12 more
wiley   +1 more source

Prior knowledge and perceived impacts of tick-borne disease education among indigenous bison workers at an annual roundtable training. [PDF]

Front Public Health
Welch AM, Reuther M, Lynch-O'Brien LI, Samuelson MM, Cross ST.   +4 more
europepmc   +1 more source

Trackable Tolerogenic Macrophages Integrate PD‐L1 and Rapamycin Signaling to Suppress Alloimmune Responses in Transplantation

Advanced Science, EarlyView.
We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.
Yihui Wang, Yuan Song, Yuji Xie, Junmin Zhang, Jing Liu, Wenyuan Wang, Ying Xu, Wenqian Wu, Wuqi Zhou, Qiaofeng Jin, Jing Wang, Yali Yang, Li Zhang, Tang Gao, Mingxing Xie   +14 more
wiley   +1 more source

First record and molecular detection of Ornithodoros maritimus Vermeil & Marguet, 1967 in Türkiye with notes on other tick species collected on the Gull Island, Sinop. [PDF]

Exp Appl Acarol
Ozsemir AC, Sonmez E, Zarrabi-Ahrabi S, Gargili-Keles A, Akyildiz G.   +4 more
europepmc   +1 more source

Coacervate‐Mediated Lysosome‐Targeting Antibody Delivery for Protein Degradation

Advanced Science, EarlyView.
Targeting coacervates to the lysosome in the cytoplasm is a challenge. Here, we convert a tetrapeptide into lysosome‐targeting, membrane‐translocating coacervates. The lysosome‐sorting peptide coacervates facilitate coacervate‐mediated delivery of antibody antigen complexes and a PROTAC compound to the lysosome for the targeted degradation of cancer ...
Dingdong Yuan, Yishu Bao, Zhiyi Xu, Zhong Zheng, Yongxu Han, Kai Cheng, Yuan‐Di Zhao, Jiang Xia   +7 more
wiley   +1 more source

Efficacy of thyme oil and nano-formulated derivatives against Rhipicephalus sanguineus sensu lato (Acari: Ixodidae). [PDF]

Sci Rep
Talep EAA, Abuowarda M, Abdel-Shafy S, Ayoob F, Abdel-Ghany HSM, Hassanen EI, Fahmy MM.   +6 more
europepmc   +1 more source

Clickable Microgel Inks Enable Spatioselective, Multi‐Stimuli Programmable Assembly of Materials

Advanced Science, EarlyView.
Clickable microgel inks enable direct ink writing of hydrogel architectures with intrinsic spatioselective and programmable multi‐responsiveness. By combining pH‐responsive and temperature‐responsive microgel building blocks through Diels‐Alder interparticle crosslinking, the assemblies exhibit controllable swelling and shape changes.
Junho Moon, Frank Gardea, Madeline A. Morales, Svetlana Sukhishvili   +3 more
wiley   +1 more source

From flyways to foci: a systematic review and meta-analysis on the role of birds in the maintenance and global dispersal of ticks and tick-borne pathogens. [PDF]

Parasit Vectors
Zu GY, Wei WN, Cao Z, Xiao XT, Yu HJ, Li C, Shen SJ, Zhou S, Gong TT, Shan C, Cao WC, Zhao L.   +11 more
europepmc   +1 more source