Results 161 to 170 of about 82,246 (321)

Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers

Advanced Science, EarlyView.
This study demonstrates that the resveratrol analogue, trans‐4,4′‐dihydroxystilbene (DHS), exhibits synergistic anti‐tumor activity with the PARP inhibitor talazoparib, inducing significant ovarian cancer cell death. The synergistic effect of this combination arises from the concurrent downregulation of homologous recombination factors and the ...
Ganesh Pai Bellare, Kshama Kundu, Papiya Dey, Krupa Thankam Philip, Nitish Chauhan, Muskan Sharma, Sankarsingh Kesharsingh Rajput, Birija Sankar Patro   +7 more
wiley   +1 more source

Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism

Advanced Science, EarlyView.
By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini, Sabrina Mechaussier, Carolina Campos Pina, Monica Morais, Olivier Postal, Philippe Jean, Typhaine Dupont, Amrit Singh‐Estivalet, Shéhanie Udugampolage, Cyril Scandola, Elisabeth Verpy, Baptiste Libé‐Philippot, Talya C. Inbar, Joanna Schwenkgrub, Carla Maria Barbosa Spinola, Raphaël Etournay, Aziz El‐Amraoui, Brice Bathellier, Adeline Mallet, Sedigheh Delmaghani, Fabrice Giraudet, Christine Petit, Boris Gourévitch, Paul Avan, Nicolas Michalski   +24 more
wiley   +1 more source

Thermo‐responsive topological metamorphosis in covalent‐and‐supramolecular polymer architectures

Aggregate, Volume 3, Issue 6, December 2022., 2022
We report a thermo‐responsive topological metamorphosis in covalent‐and‐supramolecular polymer (CSP) architectures wherein supramolecular graft polymer (SGP) transforms into supramolecular polymer network (SPN) based on collaborative dynamic covalent bond chemistry and host−guest chemistry.
Yongming Wang, Hao Zhang, Zhaoming Zhang, Jun Zhao, Ruixue Bai, Yuhang Liu, Xinhai Zhang, Xuzhou Yan   +7 more
wiley   +1 more source

Bat Ticks of the Genus Argas (Ixodoidea, Argasidae) 2. Secretargas New Subgenus and A. Transgariepinus White, 1846, Its Adult and Immature Stages; with a Definition of the Subgenus Argas1 [PDF]

, 1957
Harry Hoogstraal
openalex   +1 more source

PRMT1 Ablation in Endothelial Cells Causes Endothelial Dysfunction and Aggravates COPD Attributable to Dysregulated NF‐κB Signaling

Advanced Science, EarlyView.
This study investigates the role of protein arginine methyltransferase 1 (PRMT1) in endothelial cells (ECs) in chronic obstructive pulmonary disease (COPD). Mice with endothelial‐specific PRMT1 deletion develop pulmonary hemorrhage, inflammation, and apoptosis, driven by excessive nuclear factor kappa B activation.
Thi Thuy Vy Tran, Yideul Jeong, Suwoo Kim, Ji Eun Yeom, Jinwoo Lee, Wonhwa Lee, Gyu‐Un Bae, Jong‐Sun Kang   +7 more
wiley   +1 more source

AIE‐based drug/gene delivery system: Evolution from fluorescence monitoring alone to augmented therapeutics

Aggregate, Volume 3, Issue 6, December 2022., 2022
The aggregation‐induced emission luminogens (AIEgens) propel the development of drug and gene delivery systems. The lit‐up AIEgens first serve for real‐time monitoring of the delivery processes and evaluation of therapeutic responses of drug/gene. The delicate design of AIEgens to form high‐level structural carrier remarkably enhances the delivery ...
Jie Sun, Xuewen He
wiley   +1 more source

Affinity‐Based Isolation and One‐Pot Analysis of Extracellular Vesicles from Biofluids Using Phase Separated Zwitterionic Coacervates

Advanced Science, EarlyView.
This study presents a novel method for affinity‐based isolation and analysis of extracellular vesicles from biofluids using phase‐separated zwitterionic coacervates functionalized with a membrane‐sensing peptide. This technology minimizes nonspecific binding, enabling high‐yield isolation and direct one‐pot biomarker profiling.
Francesca Torrini, Roberto Frigerio, Jonathan Garlipp, Philippe Lenzen, Karl Normak, Carolina Paganini, Marina Cretich, Alessandro Gori, Paolo Arosio   +8 more
wiley   +1 more source

The Sucking Apparatus in Ticks [PDF]

, 1934
Souvik Sen
openalex   +1 more source

Electrostatically Reinforced Double Network Granular Hydrogels

Advanced Science, EarlyView.
Electrostatically reinforced double network granular hydrogels (DNGHs) with cartilage‐like fracture energy are introduced. An empirical model predicts the composition‐dependent fracture energy based on dissipation zone size, contact area, and inter‐particle adhesion energy. Thanks to their granular structure and the inter‐particle attraction, the DNGHs
Tianyu Yuan, Chenzhuo Li, John M. Kolinski, Esther Amstad   +3 more
wiley   +1 more source

Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea

Advanced Science, EarlyView.
This study indicates that Serpine2 plays a pivotal role in hair cell (HC) regeneration from Lgr5+ progenitors in the neonatal mouse cochlea. Conditional overexpression of Serpine2 in cochlear Lgr5+ progenitors results in a significantly increased number of ectopic HCs, particularly ectopic inner HCs, and these HCs are likely derived from Lgr5 ...
Hairong Xiao, Jiheng Wu, Lixuan Huang, Ying Ma, Leilei Wu, Yanqin Lin, Zixuan Ye, Xin Tan, Xujun Tang, Wei Tong, Mingchen Dai, Yintao Wang, Xia Sheng, Renjie Chai, Shasha Zhang   +14 more
wiley   +1 more source