Results 241 to 250 of about 291,682 (345)

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

Advanced Science, EarlyView.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha, Kyle L. MacQuarrie, Marcelo Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert Nap, Parambir S. Dulai, Igal Szleifer, Vadim Backman   +11 more
wiley   +1 more source

Investigation of Genotypes of Borrelia burgdorferi in Ixodes scapularis Ticks Collected during Surveillance in Canada

, 2011
N. H. Ogden, Gabriele Margos, David M. Aanensen, Michael Drebot, Edward J. Feil, K. Hanincová, Ira Schwartz, Shaun Tyler, L. Robbin Lindsay   +8 more
openalex   +2 more sources

Diversity of Ticks in the Caribbean Region and Detection of Their Pathogens Using BioMark Technology. [PDF]

Transbound Emerg Dis
Charles RA, Albina E, Gondard M, Aprelon R, Galon C, Trotman M, Bowen C, Melville S, Sylvester K, Musai L, Morris M, Oura C, Moutailler S, Georges K.   +13 more
europepmc   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Molecular Detection and Prevalence of <i>Coxiella burnetii</i> in Ticks from Namibia: A Regional and Genus-Specific Analysis. [PDF]

Pathogens
Mbiri P, Muleya W, Moyo E, Samkange A, Matomola OC, Charamba V, Ujava U, Hoebes EE, Chitate F, Neshindo FWT, Kapapero J, Winter C, Weiss S, Nepolo E, Pazvakawambwa L, Chitanga S.   +15 more
europepmc   +1 more source

An Opto‐Actuated Hydrogel for Cell Mechanoactuation and Real‐Time Force Monitoring

Advanced Science, EarlyView.
Researchers developed a mechanoactuated hydrogel interface where nanomachines exert forces on adhesion receptors and allow monitoring of traction force responses in real time. They demonstrate reversible talin recruitment, enhanced F‐actin polymerization, and a reduction in cell traction force when force is locally applied to focal adhesions of ...
Rinku Kumar, Marc A. Fernandez‐Yague, Adrien Bessaguet, Hosoowi Lee, Nicolas Giuseppone, Andrés J. García, Aránzazu del Campo   +6 more
wiley   +1 more source

Sexual and regional differences in the microbiome and functional metagenome of the lone star tick, Amblyomma americanum. [PDF]

Anim Microbiome
Briggs P, Trimmell L, Stiemsma LT, Monzón J.   +3 more
europepmc   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

An Evidence Based Rationale for Making Tick - borne Relapsing Fever a Nationally Notifiable Disease

, 2019
Kyle M Hatcher
openalex   +1 more source

Prevalence of Ixodid Tick Infestation Among Small Ruminants in Ethiopia: A Systematic Review and Meta-Analysis. [PDF]

Vet Med Sci
Girma A, Abdu I, Getachew A.
europepmc   +1 more source