Results 301 to 310 of about 280,062 (388)

Human iPSCs Derived MSCs‐Secreted Exosomes Modulate Senescent Nucleus Pulposus Cells Induced Macrophage Polarization via Metabolic Reprogramming to Mitigate Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
Senescent nucleus pulposus cells drive inflammatory M1 macrophage polarization, exacerbating intervertebral disc degeneration (IDD). Conversely, M1 macrophages accelerate NP cell senescence, creating a vicious cycle. iPSCs‐derived mesenchymal stem cell (iMSCs) exosomes break this loop by delivering miR‐100‐5p to suppress mTORC1/glycolysis in ...
Qian Xiang   +10 more
wiley   +1 more source

Theranostic Toolbox for Neutrophil Functionalization

open access: yesAdvanced Science, EarlyView.
Here, neutrophil‐specific fluorine nanoparticles additionally equipped with either activating or inhibiting peptides for a background‐free 19F MRI‐based nanotheranostic approach are engineered. It is demonstrated that this approach is suitable to visualize and concomitantly direct neutrophil functionality depending on the specific requirements to ...
Pascal Bouvain   +11 more
wiley   +1 more source

Mammal community composition and season determine the abundance of questing ticks in mountainous forests of central Japan. [PDF]

open access: yesInt J Parasitol Parasites Wildl
Iijima H   +5 more
europepmc   +1 more source

Beyond Planar: Enhanced Performance of Hollow Fiber Dielectric Elastomer Actuators

open access: yesAdvanced Science, EarlyView.
This study presents a comprehensive analysis of hollow fiber dielectric elastomer actuators, highlighting their superior strain performance compared to planar actuators. By combining analytical modeling, numerical simulations, and experiments, it identifies optimal fiber geometries that maximize actuation efficiency.
Sina Jafarzadeh, Anne Ladegaard Skov
wiley   +1 more source

SIRT6 Lysine‐Demyristoylates ATF2 to Ameliorate Vascular Injury via PRKCD/VE‐Cadherin Pathway Regulating Vascular Endothelial Barrier

open access: yesAdvanced Science, EarlyView.
A novel modified SIRT6 variant (dSIRT6) H133Y‐mediated enrichment technique unmasks 15 new human lysine‐myristoylated proteins. Notably, Sirtuin 6 (SIRT6) demyristoylation of activating transcription factor 2 (ATF2) at K296 orchestrates its nucleoplasmic translocation.
Runyang Feng   +40 more
wiley   +1 more source

'You adapt, and you try not to resent it': a qualitative study exploring impacts of living with ticks and barriers to adopting preventive measures in Canada. [PDF]

open access: yesBMC Public Health
Bowser N   +7 more
europepmc   +1 more source

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