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Clinical Pharmacokinetics of Ticlopidine
Clinical Pharmacokinetics, 1994Platelets contribute significantly to arterial-occlusive thrombosis, one of the major causes of death and disease throughout the world. Consequently, inhibiting platelet function is a potentially important therapeutic goal. Among agents that inhibit platelet function, ticlopidine shows a wide spectrum of antiplatelet activity. There have been a limited
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Ticlopidine-Induced Cholestatic Hepatitis
Annals of Pharmacotherapy, 2003OBJECTIVE: To report 2 cases of ticlopidine-induced cholestatic hepatitis, investigate its mechanism, and compare the observed main characteristics with those of the published cases. CASE SUMMARIES: Two patients developed prolonged cholestatic hepatitis after receiving ticlopidine following percutaneous coronary angioplasty, with complete remission ...
Zev Sthoeger +3 more
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Determination of Ticlopidine in Pharmaceutical Products
Analytical Letters, 2007Abstract The voltammetric behaviour of ticlopidine‐HCl was studied using square‐wave, sampled direct current and cyclic voltammetry. The drug showed a cathodic peak at −0.01V versus Ag/AgCl with hanging mercury drop electrode. The current was investigated using cyclic voltammetry and characterized as diffusion controlled.
Tuerkoez, Ebru, Onar, A. Nur
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Ticlopidine and Stroke Prevention
Hospital Practice, 1993(1993). Ticlopidine and Stroke Prevention. Hospital Practice: Vol. 28, No. sup5, pp. 20-22.
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VASOMODULATORY ACTION OF CLOPIDOGREL AND TICLOPIDINE
Thrombosis Research, 1997Clopidogrel is a thienopyridine derived antiplatelet drug that has currently undergone extensive clinical trials in the management of various arterial disorders related to platelet activation. While the proposed mechanism of its pharmacologic action is believed to be the inhibition of ADP mediated direct and indirect actions on platelet adhesion ...
Li Hui Yang, Jawed Fareed
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Interaction of ticlopidine with the erythrocyte membrane
Biochemical Pharmacology, 1982The membrane effects of ticlopidine on the erythrocyte membrane were explored by the spin label method at the proteic and phospholipidic levels. This spectroscopic study was completed by polyacrylamide gel electrophoresis of proteins, measurement of the protection against haemolysis and observation of the erythrocyte shape changes induced by the drug ...
Magali Sablayrolles +3 more
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Modulation of Vasoconstriction by Clopidogrel and Ticlopidine
Thrombosis Research, 1998Clopidogrel is an antiplatelet drug which has undergone extensive clinical trials in the management of stroke and other arterial disorders related to platelet activation. This agent is believed to produce the inhibition of ADP mediated direct and indirect actions leading to platelet adhesion/aggregation and other activation processes.
Debra Hoppensteadt +2 more
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Overview of Ticlopidine’s Development
1993The discovery and development of a new molecule imply the interplay of chance, audacity, and challenge, as well as lessons from failures and difficulties in reaching scientific and medical recognition of therapeutic progress. Persistent efforts and a consistent preclinical and clinical program should sustain the 10- to 15-year endeavor needed for ...
Edouard Panak, Monique Verry
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Drug Metabolism and Pharmacokinetics, 2010
Hepatotoxicity is the most frequent adverse drug reaction (ADR) in Japanese treated with ticlopidine (TP). We investigated the relationship between CYP2B6 haplotype and incidence of TP-induced hepatotoxicity in 114 Japanese patients.
N. Ariyoshi +7 more
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Hepatotoxicity is the most frequent adverse drug reaction (ADR) in Japanese treated with ticlopidine (TP). We investigated the relationship between CYP2B6 haplotype and incidence of TP-induced hepatotoxicity in 114 Japanese patients.
N. Ariyoshi +7 more
semanticscholar +1 more source
Ticlopidine inhibits phenytoin clearance
Clinical Pharmacology & Therapeutics, 1999Because cases of phenytoin toxicity during concomitant ticlopidine therapy have been reported, we investigated the effects of multiple doses of ticlopidine on phenytoin pharmacokinetics in six patients receiving phenytoin monotherapy. Two steady-state dosing rate and serum phenytoin minimum concentration (Cmin) pairs were obtained for each patient ...
David A. Flockhart +2 more
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