Results 131 to 140 of about 96,120 (294)

Construcción de las funciones trigonométricas haciendo un contraste entre la utilización y ausencia de TICs [PDF]

, 2013
La educación es responsable de alfabetizar a los individuos de una sociedad debe transformar y transformarse a sí misma a través del tiempo. Desde esta perspectiva la labor docente debe preocuparse por cambiar los paradigmas de la escuela tradicional ...
Valderrama Ramírez, Nathalia Katerin
core  

Clinical precursors of tics: an EMTICS study

, 2021
BACKGROUND: Children with Tourette syndrome (TS) often have comorbid disorders, particularly attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD).
Huyser, C, Dietrich, A, Openneer, TJC, EMTICS Collaborative Group, ., Schrag, A, Martino, D, Hoekstra, PJ   +6 more
core  

Single‐Cell RNA Sequencing and Spatial Multiomics Unveil Microglia–Mural Interactions Underlying Notoginsenoside R1 Against Ischemic Stroke

iMetaMed, EarlyView.
Integrated scRNA‐seq and spatial multiomics provide single‐cell and spatial insights into the neuroprotective effects of NGR1, a clinically validated bioactive compound from Panax notoginseng. NGR1 was associated with a shift in microglial transcriptional states away from ischemia‐associated pro‐inflammatory Adam8hi microglia and toward the protective ...
Qikun Zhao, Wenbo Guo, Yanrong Zheng, Guoqian Cui, Bingjie Wan, Shuhui Deng, Hudong Bao, Xiao Tu, Shengshuang Chen, Jie Liao, Xiaohui Fan   +10 more
wiley   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

La transformación digital en el deporte: El impacto de las TICs en la mejora del rendimiento deportivo y la experiencia del usuario: Digital transformation in sport: The Impact of ICTs on improving sports performance and user experience

Este estudio cuantitativo evaluó el impacto de las Tecnologías de la Información y la Comunicación (TICs) en el rendimiento deportivo de 100 atletas de alto rendimiento, divididos en un grupo experimental (uso de TICs) y un grupo control (métodos ...
Quishpe Veloz, Kevin Andrés, Talavera Iza , Edwin Renato, Chisag Llumiquinga , Carlos Ivan   +2 more
core   +1 more source

Controlling Growth of Ultrasmall Sub‐10 nm Silver Nanoparticles From Cotinus coggygria Scop. Extract and Evaluation of Its In Vitro Anti‐Breast Cancer, Antioxidant and Antimicrobial Activity

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study highlights the potential use of Cotinus coggygria Scop. plant extract in a single‐step synthesis of biocompatible and ultrasmall AgNPs for in vitro applications. Herein, microscopic analyses revealed that AgNP exposure did not induce appreciable morphological changes in CRL‐4010 cells, whereas MCF‐7 and MDA‐MB‐231 cells exhibited ...
Ümran Ünüvar, Tuğba Nur Aslan, Suray Pehlivanoğlu, Kübra Ece Coşkuner   +3 more
wiley   +1 more source

Defining the Clinical Phenotypic Ground Truth: Expert Interrater Agreement in Hyperkinetic Movement Disorders [PDF]

Mov Disord Clin Pract
Abstract Background Reliable clinical phenotyping is crucial for diagnosis, treatment, and research in hyperkinetic movement disorders, yet its interrater reliability remains uncertain. Objectives To quantify interrater agreement in clinical phenotyping of hyperkinetic movement disorders among experts in a large, phenotypically diverse cohort.
van der Stouwe M, Vermeulen O, Eggink W, Henriksen T, McGovern E, Smit M, Aybek S, Boon A, Brandsma R, Deik A, Erro R, Espay A, Falup‐Pecurariu C, Frucht S, Ganos C, Gatto E, Helmich R, Klein C, Koelman H, Odekerken V, Koens L, Mahajan A, Morgante F, Münchau A, Panyakaew P, Peall K, Pérez‐Dueñas B, Roze E, Sadnicka A, Schneider S, Schwingenschuh P, Serranova T, Skorvanek M, Stamelou M, Tamas G, Tinazzi M, Valadas A, Vandenberghe W, de Vries J, Zutt R, van der Veen S, Luiken R, Tuitert I, Tijssen M.   +43 more
europepmc   +2 more sources

Assessing Metabolic and Reproductive Consequences of Prenatal Paracetamol Exposure in Female CD1 Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Paracetamol is a widely used analgesic during pregnancy; however, emerging evidence suggests it may act as an endocrine/metabolism disrupting compound. Using an F1 female CD1 mouse model, this study scrutinized the long‐term metabolic and reproductive consequences linked to intrauterine paracetamol exposure.
Bita Entezari, Deniz Bozdag, Elif İnce‐Erguc, Aylin Buhur, Cansin Sirin Tomruk, Suna Sabuncuoglu, Altug Yavasoglu, Hande Gurer‐Orhan   +7 more
wiley   +1 more source

Alterations in resting‐state functional connectivity relate to psychopathology trajectories during emerging adolescence

JCPP Advances, EarlyView.
Abstract Background A general psychopathology “p‐factor” captures shared variation across psychiatric disorder categories and is associated with dysfunctions in cognitive control. Alterations in resting‐state functional connectivity (RSFC) of cognitive and attentional networks have been associated concurrently with the p‐factor in youth samples ...
Jenna Jones Devine, Garrett R. Hosterman, Jolee Sloss, Adrienne L. Romer   +3 more
wiley   +1 more source

Investigating brain activity prior to tics and modulating this activity with peripheral nerve stimulation to suppress tics in Tourette syndrome [PDF]

Tourette syndrome (TS) is a neurological disorder characterized by motor and vocal tics. It is associated with a dysfunction in the cortical-striatal-thalamic-cortical (CSTC) circuit that leads to an overexcited motor cortex resulting in the execution of
Morera Màiquez, Bàrbara
core   +3 more sources