Results 161 to 170 of about 96,120 (294)

Cannabis‐Based Oil for Pain and Other Non‐Motor Symptoms in Parkinson's Disease: A Randomized Controlled Trial

open access: yesMovement Disorders, EarlyView.
Abstract Background There is a lack of treatments for non‐motor symptoms (NMS) in Parkinson's disease (PD). Objective To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. Methods This phase II, randomized, placebo‐controlled trial evaluated a formulation containing cannabidiol (CBD; 96 mg/ml) and Δ9 ...
Gabriel T. Kubota   +14 more
wiley   +1 more source

Clinical factors predicting tic persistence into adulthood. [PDF]

open access: yesFront Psychiatry
Kaylor A   +8 more
europepmc   +1 more source

Apathy in Lewy Body Disorders: A Position Paper

open access: yesMovement Disorders, EarlyView.
Abstract Apathy is one of the most prevalent and disabling non‐motor symptoms in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), collectively referred to as Lewy body disorders (LBDs). It is associated with reduced quality of life, accelerated cognitive decline, increased caregiver burden, and poorer functional outcomes, yet remains ...
Jaime Kulisevsky   +12 more
wiley   +1 more source

Fifteen‐Year Outcomes of Bilateral Pallidal Stimulation in Isolated Generalized Dystonia: Characterization of Therapeutic Response and Emergence of Parkinsonism

open access: yesMovement Disorders, EarlyView.
Abstract Background Bilateral pallidal deep brain stimulation (GPi‐DBS) is effective for dystonia. Long‐term evolution of therapeutic benefit and emergence of parkinsonism have not been systematically characterized. Objectives To assess 15‐year dystonia outcomes and characterize parkinsonism after bilateral GPi‐DBS.
Clément Desjardins   +51 more
wiley   +1 more source

Neurological Adverse Effects Associated With Commonly Used H1‐Antihistamines: A Narrative Review of Age‐Stratified Risk Profiles in Paediatric and Geriatric Populations

open access: yesMedicine Advances, EarlyView.
This narrative review examines the neurological adverse effects associated with commonly used H1‐antihistamines, focusing on how blood–brain barrier (BBB) penetration and patient age influence central nervous system (CNS) toxicity. The major finding is that first‐generation antihistamines, because of higher CNS penetration, are associated with ...
Syeda Samia Fatima   +6 more
wiley   +1 more source

In Situ Crystallization‐Induced Coherent Interfaces for Simultaneous Toughening and Hardening of Reinforced Silicon Carbide Nanoceramic

open access: yesNational Materials, EarlyView.
This work reports the fast hot‐pressing sintering of precursor‐derived amorphous SiC raw powders to prepare HfC‐reinforced SiC nanoceramic with coherent HfC/SiC interfaces. Through the synergistic effects of nanocrystallization strengthening and interface engineering, the simultaneous enhancement of three typically competing mechanical properties, that
Shiyu Yin   +12 more
wiley   +1 more source

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