Results 71 to 80 of about 15,431 (212)

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

Advanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng, Jingyu Chen, Lang Xia, Tao Wang, Yuzhou Wang, Lei Zhang, Guofang Zhao, Long Xu, Juemin Yu, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao   +13 more
wiley   +1 more source

Land management and conservation of the habitat of Bruguiera hainesii C.G. Rogers in Vietnam

Journal of Degraded and Mining Lands Management
Comprehending the bidirectional interactions between ecosystems and plant communities is essential for ensuring the conservation and sustainable development of Bruguiera hainesii. The study identified nine accompanying plant species within a range of 1.2-
Mai Phuong Pham, Thi Thu Trang Hoang, Xuan Dao Nguyen, Quoc Khanh Nguyen, Dinh Duy Vu   +4 more
doaj   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Marine Renewable Energy Resources in Peru: A Sustainable Blue Energy for Explore and Develop

Journal of Marine Science and Engineering
The Peruvian coast covers more than 3000 km along the Pacific Ocean, being one of the richest seas in terms of biodiversity, productivity, fishing, and renewable energy potential. Marine renewable energy (MRE) in both offshore and coastal environments of
Carlos Cacciuttolo, Giovene Perez, Mivael Falcón   +2 more
doaj   +1 more source

Electric Double Layer Engineering Induces O‐Down Interfacial Water Reorientation for Efficient and Long‐Term Seawater Electrolysis

Advanced Energy Materials, EarlyView.
The additive EDTMPS inhibits hydroxides deposition by chelating with Ca2+/Mg2+. It also disrupts the hydrogen bond network of interfacial water and expands the thickness of electric double layer, promoting more free water to flip into adsorbable O‐down configuration.
Tongzhou Li, Yutong Zhao, Hongjie Zhang, Yangkai Han, Zhiwei Ren, Feng Xie, Zongping Shao, Zhigang Shao   +7 more
wiley   +1 more source

AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective

Advanced Intelligent Discovery, EarlyView.
The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley   +1 more source

Implementation of LSTM Method on Tidal Prediction in Semarang Region

Journal of Applied Informatics and Computing
Semarang is the capital of the Central Java province, located in the north and directly adjacent to the Java Sea. Having an almost flat land condition with a slope of about 0-2%, Semarang City has the opportunity to experience tidal flooding.
Panreshma Rizkha Ambadar, Dian C Rini Novitasari, Yuniar Farida, Moh Hafiyusholeh, Fajar Setiawan   +4 more
doaj   +1 more source

Integrating Reinforcement Learning With Explainable Artificial Intelligence for Real‐Time Clinical Decision Support in Dynamic Healthcare Environments

Advanced Intelligent Systems, EarlyView.
A hybrid Reinforcement Learning–Explainable AI framework integrates SHAP and LIME explanations directly into a Deep Q‐Network inference loop for real‐time ICU decision support. Trained on 18 142 mechanically ventilated stays from the eICU database, the system attains 93.0% decision accuracy, 20% fewer errors than RL alone, and a 91% clinician trust ...
Jannatul Ferdaus Disha, MD Faiaz Zaman Dehan, Kazi Md. Tanvir Anzum   +2 more
wiley   +1 more source

Tidal Oscillations in Estuaries [PDF]

Geophysical Journal International, 1964
Summary. Simple analytic solutions for tidal oscillations in estuaries, such as that of the Thames, are discussed in terms of linearized theory. It is shown that progressive waves of constant speed (gh)1/2 are peculiar to channels of constant cross section, and cannot be regarded as adequate approximations in slowly diverging estuaries as is frequently
openaire   +2 more sources