Results 71 to 80 of about 486,507 (280)

Rational Tuning of Hygroscopic Oscillation of Stacked Nanoflake Assemblies for Continuous Ambient Energy Harvesting

Advanced Materials, EarlyView.
Stacked nanoflake assembly (SNA) membranes can oscillate autonomously, offering opportunities for soft actuation and energy harvesting. This work uncovers the physical mechanism behind the sustained oscillation of SNA membranes in gradient humidity and identifies three governing dimensionless parameters, enabling rational design for optimizing SNA ...
Zijing Zhang, Jimin Fu, Gesa Zhang, Zhihua Liang, Boxun Zhang, Haimin Yao   +5 more
wiley   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

AT 2022aedm and a New Class of Luminous, Fast-cooling Transients in Elliptical Galaxies

The Astrophysical Journal Letters, 2023
We present the discovery and extensive follow-up of a remarkable fast-evolving optical transient, AT 2022aedm, detected by the Asteroid Terrestrial impact Last Alert Survey (ATLAS).
M. Nicholl, S. Srivastav, M. D. Fulton, S. Gomez, M. E. Huber, S. R. Oates, P. Ramsden, L. Rhodes, S. J. Smartt, K. W. Smith, A. Aamer, J. P. Anderson, F. E. Bauer, E. Berger, T. de Boer, K. C. Chambers, P. Charalampopoulos, T.-W. Chen, R. P. Fender, M. Fraser, H. Gao, D. A. Green, L. Galbany, B. P. Gompertz, M. Gromadzki, C. P. Gutiérrez, D. A. Howell, C. Inserra, P. G. Jonker, M. Kopsacheili, T. B. Lowe, E. A. Magnier, C. McCully, S. L. McGee, T. Moore, T. E. Müller-Bravo, M. Newsome, E. Padilla Gonzalez, C. Pellegrino, T. Pessi, M. Pursiainen, A. Rest, E. J. Ridley, B. J. Shappee, X. Sheng, G. P. Smith, G. Terreran, M. A. Tucker, J. Vinkó, R. J. Wainscoat, P. Wiseman, D. R. Young   +51 more
doaj   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Bio‐Inspired Internal Stress Engineering for Microscale Surface Cracking in Sensitive Strain Sensors

Advanced Science, EarlyView.
This study presents a bio‐inspired internal stress engineering strategy to fabricate highly sensitive crack‐based strain sensors. By harnessing the internal expansion energy of microspheres and the thickness‐dependent brittle‐to‐ductile transition of ultrathin gold films, tunable microscale cracks are generated.
Jae Yeong Jang, Hanchul Cho, Young Jung
wiley   +1 more source

On the tidal disruption of a spherical galaxy [PDF]

Monthly Notices of the Royal Astronomical Society, 1991
The disruption of a satellite galaxy as it undergoes collision with a massive perturber is investigated by numerical simulations. Our models are restricted by a constant pericentric distance. The disruption of the satellite is estimated in terms of the density ratio ρ/ρ R where ρ is the initial density of the satellite and ρ R a critical density, the
P. M. S. Namboodiri, R. K. Kochhar
openaire   +1 more source

Electric Double Layer Engineering Induces O‐Down Interfacial Water Reorientation for Efficient and Long‐Term Seawater Electrolysis

Advanced Energy Materials, EarlyView.
The additive EDTMPS inhibits hydroxides deposition by chelating with Ca2+/Mg2+. It also disrupts the hydrogen bond network of interfacial water and expands the thickness of electric double layer, promoting more free water to flip into adsorbable O‐down configuration.
Tongzhou Li, Yutong Zhao, Hongjie Zhang, Yangkai Han, Zhiwei Ren, Feng Xie, Zongping Shao, Zhigang Shao   +7 more
wiley   +1 more source

Integrating Reinforcement Learning With Explainable Artificial Intelligence for Real‐Time Clinical Decision Support in Dynamic Healthcare Environments

Advanced Intelligent Systems, EarlyView.
A hybrid Reinforcement Learning–Explainable AI framework integrates SHAP and LIME explanations directly into a Deep Q‐Network inference loop for real‐time ICU decision support. Trained on 18 142 mechanically ventilated stays from the eICU database, the system attains 93.0% decision accuracy, 20% fewer errors than RL alone, and a 91% clinician trust ...
Jannatul Ferdaus Disha, MD Faiaz Zaman Dehan, Kazi Md. Tanvir Anzum   +2 more
wiley   +1 more source