Results 141 to 150 of about 2,852 (259)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

open access: yesEpilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang   +3 more
wiley   +1 more source

Ketogenic diet for infantile epileptic spasms

open access: yesEpilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury   +3 more
wiley   +1 more source

Turning the TIDE: Paediatric Provider Perspectives on Implementing a Transition Intervention for Eating Disorders

open access: yesEuropean Eating Disorders Review, EarlyView.
ABSTRACT Objective This qualitative study aimed to explore paediatric providers' perspectives on the acceptability, feasibility, and appropriateness of the Transition Intervention for Eating Disorders (TIDE) within existing specialised paediatric eating disorder (ED) programs to inform its refinement and implementation in real‐world clinical settings ...
Maria Nicula   +3 more
wiley   +1 more source

Hybrid Simulation–Machine Learning Surrogates for Coordinate‐Based Solar and Wind Energy Yield Assessment in Iraq: A Streamlit Decision‐Support Tool

open access: yesEnergy Science &Engineering, EarlyView.
This study integrates climatic simulations with machine learning to predict solar and wind energy across Iraq. Results show Random Forest excels for solar (R2 = 0.98) and neural networks for wind (R2 = 0.97), enabling a practical web tool for renewable energy planning. ABSTRACT Driven by the global shift away from fossil fuels, solar and wind resources
Bassam Musheer Kareem   +3 more
wiley   +1 more source

Integrated Solar and Wind Energy Systems for Domestic Power Generation and CO2 Emissions Reduction

open access: yesEnergy Science &Engineering, EarlyView.
A well‐structured and sequentially methodical procedure for evaluating the Wind and Photovoltaic Hybrid Energy System‐based technical, environmental, and economic viability. This study investigates the integration of solar photovoltaic(PV) and wind energy systems for domestic electricity generation in the Gaza Strip.
Mohamed Elnaggar   +9 more
wiley   +1 more source

Trendelenburg positioning with or without norepinephrine infusion for haemodynamic support in anaesthetised hypovolemic horses

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Intraoperative haemorrhage during equine anaesthesia is a rare but potentially fatal complication requiring prompt haemodynamic support. Postural manoeuvres such as Trendelenburg (TL) positioning and vasopressor support augment venous return and improve cardiac output (CO), yet their efficacy in anaesthetised hypovolemic horses ...
Vaidehi V. Paranjape   +3 more
wiley   +1 more source

Dexmedetomidine infusions improve cardiovascular and renal function in anaesthetised, experimentally endotoxaemic horses

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Dexmedetomidine infusions are beneficial in anaesthetised endotoxaemic horses when administered concurrent to endotoxin, but post‐conditioning effects are unknown. Objectives To evaluate whether a dexmedetomidine infusion is beneficial in horses administered Escherichia coli O55:B5 lipopolysaccharides (LPS) endotoxin prior to ...
Sera Lee   +4 more
wiley   +1 more source

Fatalities within seven days after equine standing sedation: A prospective, multicentre study

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Information regarding mortality associated with standing procedures in horses is sparse. Objectives To report data from >12,000 standing sedations. Study Design Confidential, observational, prospective, multicentre, cohort study.
Miguel Gozalo‐Marcilla   +6 more
wiley   +1 more source

Effect of exercise‐related nasopharyngeal disorders on upper airway function in racehorses

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Exercise‐related upper respiratory tract (URT) disorders are frequently diagnosed in racehorses. Treatment recommendations are routinely based on subjective assessment of clinical evaluation and exercising endoscopy findings. Objectives To objectively investigate how palatal instability (PI), intermittent dorsal displacement of the ...
Hanna Vermedal   +4 more
wiley   +1 more source

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