Results 101 to 110 of about 70,999 (258)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Tidal Volume [PDF]

, 2020
openaire   +1 more source

Uneven Impacts of Seawall Heightening on Tsunami Risk Reduction under Rising Sea Levels: Probabilistic Scenarios from the Japan Trench

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Disasters exacerbated by climate change have prompted adaptation measures, including seawall heightening, which is an effective approach to protecting coastal areas. However, the combined effect of rising sea levels and tsunamis can create a compound coastal hazard, in which long‐term sea level rise amplifies the impact of tsunamis.
Yushi Miki, Anawat Suppasri, Constance Ting Chua, An‐Chi Cheng, Tomoya Iwasaki, Yugo Shinozuka, Takafumi Ogawa, Fumihiko Imamura   +7 more
wiley   +1 more source

Spatial Variations in Methane Content and Their Main Controlling Factors of the Deep‐Buried Coalbed in the Nalinhe–Hengshan Area, Ordos Basin

Energy Science &Engineering, EarlyView.
Ash yield is the primary geological factor controlling the spatial variations in the total gas content of the deep‐buried coalbed methane in the Nalinhe‐Hengshan area, Ordos Basin. However, porosity dominates the differential enrichment of the free gas content of the deep‐buried coalbed methane in the Nalinhe‐Hengshan area, Ordos Basin.
Shi Yunhe, Wang Kangle, Wang Huaichang, Wang Yufei, Zhang Hui, Cao Jingjing, Yin Liangliang, Hu Xinyou, Liang Chao, Liu Mina   +9 more
wiley   +1 more source

Trendelenburg positioning with or without norepinephrine infusion for haemodynamic support in anaesthetised hypovolemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Intraoperative haemorrhage during equine anaesthesia is a rare but potentially fatal complication requiring prompt haemodynamic support. Postural manoeuvres such as Trendelenburg (TL) positioning and vasopressor support augment venous return and improve cardiac output (CO), yet their efficacy in anaesthetised hypovolemic horses ...
Vaidehi V. Paranjape, Klaus Hopster, Ismar Lutvikadic, Bernd Driessen   +3 more
wiley   +1 more source

Dexmedetomidine infusions improve cardiovascular and renal function in anaesthetised, experimentally endotoxaemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Dexmedetomidine infusions are beneficial in anaesthetised endotoxaemic horses when administered concurrent to endotoxin, but post‐conditioning effects are unknown. Objectives To evaluate whether a dexmedetomidine infusion is beneficial in horses administered Escherichia coli O55:B5 lipopolysaccharides (LPS) endotoxin prior to ...
Sera Lee, Rachel C. Hector, Lynn Pezzanite, Eric Gilleland, Marlis L. Rezende   +4 more
wiley   +1 more source

Effect of exercise‐related nasopharyngeal disorders on upper airway function in racehorses

Equine Veterinary Journal, EarlyView.
Abstract Background Exercise‐related upper respiratory tract (URT) disorders are frequently diagnosed in racehorses. Treatment recommendations are routinely based on subjective assessment of clinical evaluation and exercising endoscopy findings. Objectives To objectively investigate how palatal instability (PI), intermittent dorsal displacement of the ...
Hanna Vermedal, Ingunn Risnes Hellings, Zoe L. Fretheim‐Kelly, Constanze Fintl, Eric Strand   +4 more
wiley   +1 more source

Oscillometric assessment of bronchodilator response in horses with severe asthma during remission

Equine Veterinary Journal, EarlyView.
Abstract Background During clinical remission of severe equine asthma (SEA), affected animals can be challenging to distinguish from healthy horses. In humans, the degree of bronchodilation achieved with a β2‐adrenergic bronchodilator is helpful in differentiating asthmatics from healthy subjects.
Séléna de Wasseige, Sophie Mainguy‐Seers, Jean‐Pierre Lavoie   +2 more
wiley   +1 more source

Borophene‐based sensing platforms: Pioneering ultrasensitive detection

FlexMat, EarlyView.
Schematic Diagram of Performance Optimization Strategies and Sensing Application Characteristics of Two‐Dimensional Boron‐Based Materials in Novel Sensors. Abstract Borophene is an emerging two‐dimensional (2D) material. Since significant breakthroughs were achieved in the experimental synthesis of borophene, the exploration and development of ...
Chi Yuan, Yanpeng Ji, Yi Liu, Guoan Tai
wiley   +1 more source