Results 171 to 180 of about 274,104 (297)

Napabucasin transforms liver microenvironment and boosts immunotherapy efficacy by converting potential metastases into “hot” tumors

open access: yesInterdisciplinary Medicine, EarlyView.
Napabucasin reduces liver metastases by reprogramming the hepatic microenvironment. It induces hepatocyte secretion of CCL21 via c‐Fos activation, recruiting lymphocytes and converting “cold” metastases into immunologically “hot” tumors. This effect is liver‐specific and independent of cancer cells.
Qiongqiong Wang   +19 more
wiley   +1 more source

Visual Patterns of Diaphragmatic Motion in Acute Respiratory Failure: A Prospective Pilot Study

open access: yesJournal of Clinical Ultrasound, Volume 53, Issue 3, Page 421-428, March/April 2025.
In this prospective bicentric study, we studied the relationship between the appearance of diaphragmatic motion and the etiological diagnosis of patients admitted to the emergency department with ARF. We observed a different visual pattern in patients with pneumonia. This is an interesting result as it allows the diagnosis of pneumonia without the need
Thibaut Markarian   +7 more
wiley   +1 more source

Trajectory of irritability in children and youth in Ontario, Canada, throughout the COVID‐19 pandemic

open access: yesJCPP Advances, EarlyView.
This study explored how irritability in children and youth changed during the COVID‐19 pandemic and its impact on mental health. Results showed a gradual decline in irritability, with factors like age, parental anxiety, and resilience influencing its trajectory.
Theodore C. K. Cheung   +12 more
wiley   +1 more source

Evaluating the Air Respiratory Capacity of Awaous (Chonophorus) tajasica (Gobiiformes: Oxudercidae): A Morpho‐Functional Study

open access: yesJournal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
We demonstrated that Awaous tajasica performs facultative air breathing under experimental conditions of dissolved oxygen limitation, retaining air bubbles in the buccal cavity during gill ventilation. Morpho‐functional evidence indicates the use of atmospheric oxygen as a respiratory support under conditions of low water oxygenation.
João Pedro Trevisan   +3 more
wiley   +1 more source

Comparison of Single‐Breath and Multi‐Breath Xe‐MRI in the Longitudinal Assessment of Treatment in Children With Cystic Fibrosis

open access: yesJournal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Elexacaftor/tezacaftor/ivacaftor (ETI) is a current standard therapy for pediatric cystic fibrosis (CF). Multiple‐breath washout 129Xe MRI (MBW Xe‐MRI) is improved following 1 month of treatment. However, the utility of MBW Xe‐MRI over extended ETI treatment and its comparison to single‐breath Xe‐MRI and pulmonary function tests ...
Faiyza S. Alam   +6 more
wiley   +1 more source

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