Results 191 to 200 of about 9,336 (277)

Xanomeline and Trospium Chloride: Mechanism of Action, Clinical, and Translational Science

Clinical and Translational Science, Volume 19, Issue 9, September 2026.
ABSTRACT Xanomeline‐trospium chloride (Cobenfy, formerly KarXT) is a first‐in‐class, oral central M1/M4 muscarinic receptor agonist approved for the treatment of schizophrenia in adults. Cobenfy represents a paradigm shift by avoiding direct dopamine D2 receptor blockade and thus significantly reduces the burden of metabolic, extrapyramidal, and ...
Samantha Avila, Ingrid L. Chen
wiley   +1 more source

Sensitive neoantigen discovery by real-time mutanome-guided immunopeptidomics. [PDF]

Nat Commun
Shapiro IE, Huber F, Michaux J, Bassani-Sternberg M.   +3 more
europepmc   +1 more source

Real‐World Evidence for Existing Anti‐Obesity Therapies—The Realities of Treatment Adherence, Tolerability, Access and Patient Satisfaction

Diabetes, Obesity and Metabolism, Volume 28, Issue S5, Page 3-26, September 2026.
ABSTRACT Background Obesity is associated with substantial cardiometabolic and psychosocial morbidity. Although randomized controlled trials demonstrate the efficacy of anti‐obesity therapies, outcomes in real‐world practice may be attenuated due to limited access, tolerability, adherence and insufficient long‐term support.
Sameer Kassem
wiley   +1 more source

Interactions between live attenuated influenza vaccine and nasopharyngeal microbiota among children aged 24-59 months in The Gambia: a phase 4, open-label, randomised controlled trial. [PDF]

Lancet Microbe
Peno C, Jagne YJ, Clerc M, Balcazar Lopez C, Armitage EP, Sallah H, Drammeh S, Senghore E, Goderski G, van Tol S, Meijer A, Ruiz-Rodriguez A, de Steenhuijsen Piters WAA, de Koff E, Jarju S, Lindsey BB, Camara J, Bah S, Mohammed NI, Kampmann B, Clarke E, Dockrell DH, de Silva TI, Bogaert D.   +23 more
europepmc   +1 more source

Staged Management of Extensive Suprapubic Wound Necrosis After Hysterectomy Using Negative Pressure Wound Therapy and Delayed Skin Grafting

International Wound Journal, Volume 23, Issue 9, September 2026.
ABSTRACT Postoperative wound complications are a major clinical challenge, especially in patients with comorbidities such as overweight and diabetes mellitus. Extensive abdominal wall necrosis after gynaecologic surgery is uncommon but may lead to prolonged healing, increased morbidity and the need for complex reconstructive procedures.
Stefano Restaino, Edoardo Farnè, Martina Arcieri, Marta Bortolozzo, Anna Momic, Tina Moni Bidin, Beatrice Nonino, Irene Silvestri, Glenda Caputo, Marco D'Asta, Marco Petrillo, Guglielmo Stabile, Lorenza Driul, Giuseppe Vizzielli   +13 more
wiley   +1 more source

Safety of One-Piece Hydrophilic Acrylic Intraocular Lenses in the Ciliary Sulcus. [PDF]

J Clin Med
Sharon T, Lippin N, Yehezkeli V, Dar N, Belkin A, Assia EI.   +5 more
europepmc   +1 more source

Clinical Characterization of Glaucoma in 63 Pet Rabbits (Oryctolagus cuniculus) in Japan

Veterinary Ophthalmology, Volume 29, Issue 5, September 2026.
ABSTRACT Objective To characterize the signalment and clinical presentation of glaucoma in pet rabbits. Animal Studied Client‐owned pet rabbits (n = 222) referred to an exotic specialty animal hospital for ophthalmic examination between 2007 and 2023.
Kumiko Kato, Makoto Nakata, Yasutsugu Miwa, Keiko Miyadera   +3 more
wiley   +1 more source

Tid for tango? [PDF]

Tidsskrift for Den norske legeforening, 2015
openaire   +1 more source

Urine electrolytes guide treatment of Gitelman syndrome and recurrent syncope—A case report

Physiological Reports, Volume 14, Issue 18, September 2026.
Abstract Syncope is a common reason for inpatient admission. Few case studies describe an association between syncope and Gitelman syndrome (GS). Herein, we present a case of a woman with hypokalemia and recurrent syncope which eventually led to a diagnosis of GS. A physiologic approach to urine electrolyte interpretation informed clinical decisions to
Saloni Agrawal, Kenneth M. Fifer, Samira S. Farouk, Joshua L. Rein   +3 more
wiley   +1 more source

Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy. [PDF]

Sci Adv
Kapoor R, Kim H, Garlick E, Lima MADRBF, Esch K, Ruhwedel T, Möbius W, Wolf F, Moser T.   +8 more
europepmc   +1 more source