Results 101 to 110 of about 87,683 (308)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Tight points and countable fan-tightness
Topology and its Applications, 1997 A family \(\mathcal E\) of subsets of a space \(X\) clusters at a point \(p \in X\) if for every neighbourhood \(U\) of \(p\) there is a member \(E\) in \(\mathcal E\) such that the set \(E \cap U\) is infinite. A point \(p\) is a tight point of \(X\) if for every family \(\mathcal E\) of subsets of \(X\) which clusters at \(p\) there is a countable ...
BELLA, Angelo, van Mill, J.
openaire +2 more sources
Relationship between Tightness-Looseness and Political Instability.
, 2015 Relationship between Tightness-Looseness and Political Instability.
Pawel Boski (750103) +2 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Relationship between Tightness-Looseness and Life Expectancy.
, 2015 Relationship between Tightness-Looseness and Life Expectancy.
Pawel Boski (750103) +2 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Relationship between Tightness-Looseness and Composite Score.
, 2015 Relationship between Tightness-Looseness and Composite Score.
Pawel Boski (750103) +2 more
core +1 more source
Wage effects of labor market tightness [PDF]
, 2022 I provide new microeconometric estimates of the effect of labor market tightness on wages at the firm level. Using Danish data on vacancies and unemployment at the occupational level and firm data on the occupational composition of employees, I construct
Hoeck, Christian Philip
core