Results 171 to 180 of about 277,783 (271)

PharmVar GeneFocus: NAT2—Genetic Variation and Updated Nomenclature

Clinical Pharmacology &Therapeutics, EarlyView.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human N‐acetyltransferase 2 (NAT2) gene. NAT2 metabolizes several clinically used drugs including isoniazid, hydralazine, amifampridine, procainamide, and sulfonamides such as dapsone, and also some highly carcinogenic arylamines.
Georgia Papanikolaou, Estella S. Poloni, José A.G. Agúndez, Raquel L.F. Teixeira, Erin C. Boone, Adalberto Rezende Santos, Michelle Whirl‐Carrillo, Katrin Sangkuhl, Teri E. Klein, Mariam R. Habil, Giannoulis Fakis, Rodney F. Minchin, David W. Hein, Sotiria Boukouvala, Andrea Gaedigk   +14 more
wiley   +1 more source

Valorizing the applicability of waste rubber tiles loaded with bagasse fibers in different epoxy resin systems. [PDF]

Sci Rep
Elsayed Eldesoky AE, Khalil AM, Haroun AAA, Kamel S.   +3 more
europepmc   +1 more source

Whole tissue imaging of cellular boundaries at sub‐micron resolutions for deep learning cell segmentation: Applications in the analysis of epithelial bending of ectoderm

Developmental Dynamics, EarlyView.
Abstract Background To understand cellular morphology, biologists have relied on traditional optical microscopy of tissues combined with tissue clearing protocols to image structures deep within tissues. Unfortunately, these protocols often struggle to retain cell boundary markers, especially at high enough resolutions necessary for precise cell ...
Sam C. P. Norris, Jimmy K. Hu, Neil H. Shubin   +2 more
wiley   +1 more source

Designer RNA nanostructures co-transcribed and self-assembled inside human cell nuclei. [PDF]

Nat Commun
Chang X, Jeziorek M, Yang Q, Bonder EM, Yan H, Etchegaray JP, Zhang F.   +6 more
europepmc   +1 more source

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

Quantitative Assessment of Focus Quality in Whole-Slide Imaging of Thyroid Liquid-Based Cytology Using Laplacian Variance. [PDF]

Endocr Pathol
Jung CK, Kim C, Jeon S, Bychkov A.
europepmc   +1 more source

Oogenesis and germinal bed morphology of the brown anole (A. sagrei)

Developmental Dynamics, EarlyView.
Abstract Background The brown anole is a model species of the genus Anolis, a squamate (encompassing lizards and snakes) group widely studied in evolutionary, behavioral, and developmental biology. Full genome annotation, the establishment of gene editing techniques, and comprehensive description of reproductive tract morphology and embryogenesis in ...
Bonnie K. Kircher, Antonia Weberling, Erin J. Vance, Natalia A. Shylo, Katherine Starr, Zoe B. Griffin, Hannah Wilson, Melainia McClain, Florian Hollfelder, Suzannah A. Williams, Thomas J. Sanger, Richard R. Behringer, Paul A. Trainor   +12 more
wiley   +1 more source

Whose city is it? Mapping perceived urban livability with citizen-guided AI. [PDF]

NPJ Urban Sustain
Campomanes V F, Abascal A, Oliveira LT, Kuffer M, Dijkstra AM, Stein A, Belgiu M.   +6 more
europepmc   +1 more source

Physiology–microhabitat matching may help organisms cope with the thermal and hydric challenges under climate change: a tale of two lizards

Ecography, EarlyView.
Climate change is significantly affecting biodiversity, and organisms that depend on external temperature – such as ectotherms – are particularly vulnerable to these effects. Microhabitats provide refuge for species, thereby reducing exposure to thermal and hydric stress under climate change.
Carolina Reyes‐ Puig, Antigoni Kaliontzopoulou, Neftalí Sillero, Urtzi Enriquez‐ Urzelai   +3 more
wiley   +1 more source

Translational deep learning models for risk stratification to predict prognosis and immunotherapy response in gastric cancer using digital pathology. [PDF]

J Transl Med
Nguyen MH, Do-Huu HH, Nguyen PT, Tran ND, Linh NT, Le H, Le NQK.   +6 more
europepmc   +1 more source