Results 71 to 80 of about 266,578 (324)

Post-coronagraphic tip-tilt sensing for vortex phase masks: the QACITS technique [PDF]

, 2015
Small inner working angle coronagraphs, like the vortex phase mask, are essential to exploit the full potential of ground-based telescopes in the context of exoplanet detection and characterization.
Absil, Olivier, Baudoz, Pierre, Huby, Elsa, Mawet, Dimitri   +3 more
core   +4 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Study on Centroid Height Prediction of Non-Rigid Vehicle Based on Deep Learning Combined Model

Sensors
The height of the center of gravity (ZCG) is a critical parameter for evaluating vehicle safety and performance. Systematic errors arise in ZCG measurement via the tilt-table test method due to unlocked suspension systems and variable sprung mass ...
Guoqiang Pang, Zhiquan Xiao, Zhanwen Cai, Pei Wang   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Usefulness of Tilt Testing in Children with Syncope: A Survey of Pediatric Electrophysiologists

Indian Pacing and Electrophysiology Journal, 2008
The role of tilt table testing as a diagnostic modality in children with unexplained syncope is unclear. We sent a questionnaire to members of the Pediatric and Congenital Electrophysiology Society to assess the current practice pattern.
Anjan S. Batra, Seshadri Balaji
doaj  

Relationship between the mean platelet volume values and tilt-table test results in patients with vasovagal syncope

Medicine Science, 2018
Impaired sympathovagal balance, the main pathophysiological mechanism under the vasovagal syncope (VVS), may play a role on platelet sizes. Although it has been shown that mean platelet volume (MPV) is increased in patients with vasovagal syncope, its ...
Yalcin Gokoglan, Erkan Yildirim
doaj   +1 more source

Proto-Model of an Infrared Wide-Field Off-Axis Telescope [PDF]

, 2010
We develop a proto-model of an off-axis reflective telescope for infrared wide-field observations based on the design of Schwarzschild-Chang type telescope.
Chang, Seunghyuk, Kim, Geon Hee, Kim, Myung Sang, Kim, Sanghyuk, Lee, Hanshin, Lee, Sungho, Pak, Soojong, Yang, Sun Choel   +7 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source