Results 41 to 50 of about 27,300 (256)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Usefulness of Tilt Testing in Children with Syncope: A Survey of Pediatric Electrophysiologists

Indian Pacing and Electrophysiology Journal, 2008
The role of tilt table testing as a diagnostic modality in children with unexplained syncope is unclear. We sent a questionnaire to members of the Pediatric and Congenital Electrophysiology Society to assess the current practice pattern.
Anjan S. Batra, Seshadri Balaji
doaj  

Improved Patient Outcomes by Normalizing Sympathovagal Balance: Differentiating Syncope—Precise Subtype Differentiation Leads to Improved Outcomes

Cardiology Research and Practice, 2018
Syncope is difficult to definitively diagnose, even with tilt-table testing and beat-to-beat blood pressure measurements, the gold-standard. Both are qualitative, subjective assessments.
Nicholas L. DePace, Julie A. Bateman, Michael Yayac, John Oh, Mushfiqur Siddique, Cesar Acosta, Jeysel M. Pinales, Aaron I. Vinik, Heather L. Bloom   +8 more
doaj   +1 more source

Orthostatic intolerance as a potential contributor to prolonged fatigue and inconsistent performance in elite swimmers

BMC Sports Science, Medicine and Rehabilitation, 2022
Background Athletic underperformance is characterized by fatigue and an inability to sustain a consistent exercise workload. We describe five elite swimmers with prolonged fatigue and athletic underperformance.
Lindsay S. Petracek, Ella F. Eastin, Ian R. Rowe, Peter C. Rowe   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Unconfined interfacial friction of Geosynthetic Cementitious Composite Mats [PDF]

E3S Web of Conferences
Geosynthetic Cementitious Composite Mats (GCCMs) are flexible, cementitious material-filled geosynthetics that harden on hydration to form thin concrete layers and are primarily used for surface erosion protection applications.
Church Lee, Plumridge Charles, Koerner George   +2 more
doaj   +1 more source

Tilt-table test: its role in modern practice [PDF]

Clinical Medicine, 2013
Syncope is a major healthcare problem with significant morbidity, mortality and healthcare cost. It is a common symptom with a complex pathophysiology and, therefore, several aetiologies. Tilt-table testing (TTT) is an important, yet perhaps not widely-used, test that forms part of the management of syncope.
Kulwinder S, Sandhu, Pervez, Khan, John, Panting, Sunil, Nadar   +3 more
openaire   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Orthostatic and Supine Blood Pressures Are Associated with White Matter Hyperintensities in Parkinson Disease [PDF]

Journal of Movement Disorders, 2013
Background and Purpose: Several reports on the elderly population have suggested that orthostatic hypotension is associated with white matter hyperintensities (WMH); however, little information is available on patients with Parkinson’s disease (PD ...
Yoon-Sang Oh, Joong-Seok Kim, Kwang-Soo Lee   +2 more
doaj   +1 more source

Cerebral blood flow remains reduced after tilt testing in myalgic encephalomyelitis/chronic fatigue syndrome patients

Clinical Neurophysiology Practice, 2021
Objective: Orthostatic symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may be caused by an abnormal reduction in cerebral blood flow.
C. (Linda) M.C. van Campen, Peter C. Rowe, Frans C. Visser   +2 more
doaj   +1 more source