Thermal Management and Reliability Engineering of Advanced HBM Packages: Materials, Interfaces, and Integrated Design Strategies. [PDF]
Do HR +5 more
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The impact of T cell exhaustion in hematopoietic stem cell transplantation. [PDF]
Li Y +6 more
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Confusing Uncertainty With Bias: The Challenges of Working With Real-World Data. [PDF]
Wilson J +12 more
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The Signaling Networks of TIM-3, TGF-β, and STING in Glioblastoma. [PDF]
Ahmady-Nield F +7 more
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Decoding Galectin-Glycan Recognition with <sup>19</sup>F-Tagged Lectins: from Simple Glycans to the Cellular Glycocalyx. [PDF]
Bartoloni M +12 more
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Soluble Uric Acid Drives CD8+ T-cell Exhaustion by Inducing KSR1-Mediated MAPK Hyperactivation. [PDF]
Liu A +12 more
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Tim-3 and Tim-4 as the potential targets for antitumor therapy [PDF]
Both Tim-3 and Tim-4 belong to the T-cell immunoglobulin and mucin domain (Tim) gene family, which plays a critical role in immunoregulation. Tim-3 has been suggested as a negative regulator of anti-tumor immunity due to its function on inducing T cells exhaustion in cancer.
Lin Cheng, Zhihua Ruan
exaly +3 more sources
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TIM-4 is the ligand for TIM-1, and the TIM-1–TIM-4 interaction regulates T cell proliferation
Nature Immunology, 2005The newly identified TIM family of proteins is associated with regulation of T helper type 1 (T(H)1) and T(H)2 immune responses. TIM-1 is genetically linked to asthma and is a receptor for hepatitis A virus, but the endogenous ligand of TIM-1 is not known. Here we show that TIM-4, which is expressed by antigen-presenting cells, is the ligand for TIM-1.
Jennifer Hartt, Meyers +11 more
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