Results 31 to 40 of about 21,385 (219)

A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms.

PLoS ONE, 2019
Second-generation mammalian target of rapamycin (mTOR) inhibitors such as CC-223 may have theoretical advantages over first-generation drugs by inhibiting TOR kinase in mTOR complex 1 (mTORC1) and 2 (mTORC2), potentially improving clinical efficacy for ...
Edward Wolin, Alain Mita, Amit Mahipal, Tim Meyer, Johanna Bendell, John Nemunaitis, Pam N Munster, Luis Paz-Ares, Ellen H Filvaroff, Shaoyi Li, Kristen Hege, Hans de Haan, Monica Mita   +12 more
doaj   +1 more source

ALMA Maps of Dust and Warm Dense Gas Emission in the Starburst Galaxy IC 5179$^\star$ [PDF]

, 2017
We present our high-resolution ($0^{\prime\prime}.15\times0^{\prime\prime}.13$, $\sim$34 pc) observations of the CO(6-5) line emission, which probes the warm and dense molecular gas, and the 434 $\mu$m dust continuum emission in the nuclear region of the
Cao, Chen, Charmandaris, Vassilis, Diaz-Santos, Tanio, Gao, Yu, Lu, Nanyao, van der Werf, Paul, Xu, C. Kevin, Zhang, Zhi-Yu, Zhao, Yinghe   +8 more
core   +3 more sources

Hybrid Magnetoactive Soft Elastomers: Material Development Toward Application in Diaphragm Pumps

Advanced Materials Technologies, EarlyView.
Hybrid magnetoactive soft elastomeric membranes are developed by combining two different types of magnetic particles. The membranes exhibit distinct mechanical, magnetic and thermal properties owing to the unique characteristics of the two magnetic particles.
Somashree Mondal, Paweł Orkisz, Bogdan Sapiński, Ralph Spolenak, Frank Clemens   +4 more
wiley   +1 more source

Additive Manufacturing of Ni‐Based Thermoelectric Materials for Waste Heat Recovery

Advanced Materials Technologies, EarlyView.
Thermoelectric generators convert waste heat into electricity but are constrained by conventional fabrication. Here, laser powder bed fusion enables direct printing of customised n‐type Cu60Ni40 and p‐type Ni90Cr10 legs. The assembled module achieves 0.8% efficiency at ΔT = 419 K, demonstrating scalable additive manufacturing of eco‐friendly, design ...
Karolin Amstein, Aayush Dobhal, Heiko Reith, Ran He, Julia Kristin Hufenbach, Kornelius Nielsch, Pingjun Ying   +6 more
wiley   +1 more source

Efficacy of Acceptance and Commitment Therapy in Daily Life (ACT-DL) in early psychosis: study protocol for a multi-centre randomized controlled trial

Trials, 2019
Background Psychotic experiences, social functioning and general psychopathology are important targets for early intervention in individuals with Ultra-High-Risk state (UHR) and a first-episode psychosis (FEP).
Ulrich Reininghaus, Annelie Klippel, Henrietta Steinhart, Thomas Vaessen, Martine van Nierop, Wolfgang Viechtbauer, Tim Batink, Zuzana Kasanova, Evelyne van Aubel, Ruud van Winkel, Machteld Marcelis, Therese van Amelsvoort, Mark van der Gaag, Lieuwe de Haan, Inez Myin-Germeys   +14 more
doaj   +1 more source

Uncovering renewable energy policy impact channels on land values, the local farm structure, and farmland heterogeneity

American Journal of Agricultural Economics, EarlyView.
Abstract Germany's Renewable Energy Sources Act (REA), enacted in 2000 and subsequently amended, subsidized national renewable energy production with fixed feed‐in tariffs for renewable energy sources (RE) from wind, solar, and biogas. Empirical studies suggest that the policy was creating windfall effects for landowners and attribute farmland use ...
Lars Isenhardt, Stefan Seifert, Saskia Wolff, Tobia Lakes, Marten Graubner, Axel Werwatz, Silke Hüttel   +6 more
wiley   +1 more source

Individualized Prediction of Transition to Psychosis in 1,676 Individuals at Clinical High Risk: Development and Validation of a Multivariable Prediction Model Based on Individual Patient Data Meta-Analysis

Frontiers in Psychiatry, 2019
Background: The Clinical High Risk state for Psychosis (CHR-P) has become the cornerstone of modern preventive psychiatry. The next stage of clinical advancements rests on the ability to formulate a more accurate prognostic estimate at the individual ...
Aaltsje Malda, Aaltsje Malda, Nynke Boonstra, Nynke Boonstra, Hans Barf, Steven de Jong, Andre Aleman, Andre Aleman, Jean Addington, Marita Pruessner, Marita Pruessner, Dorien Nieman, Lieuwe de Haan, Anthony Morrison, Anthony Morrison, Anita Riecher-Rössler, Erich Studerus, Stephan Ruhrmann, Frauke Schultze-Lutter, Suk Kyoon An, Shinsuke Koike, Shinsuke Koike, Shinsuke Koike, Shinsuke Koike, Kiyoto Kasai, Kiyoto Kasai, Kiyoto Kasai, Kiyoto Kasai, Barnaby Nelson, Barnaby Nelson, Patrick McGorry, Patrick McGorry, Stephen Wood, Stephen Wood, Stephen Wood, Ashleigh Lin, Alison Y. Yung, Alison Y. Yung, Alison Y. Yung, Alison Y. Yung, Magdalena Kotlicka-Antczak, Marco Armando, Marco Armando, Stefano Vicari, Masahiro Katsura, Kazunori Matsumoto, Kazunori Matsumoto, Kazunori Matsumoto, Sarah Durston, Tim Ziermans, Tim Ziermans, Lex Wunderink, Lex Wunderink, Helga Ising, Mark van der Gaag, Mark van der Gaag, Paolo Fusar-Poli, Paolo Fusar-Poli, Paolo Fusar-Poli, Paolo Fusar-Poli, Gerdina Hendrika Maria Pijnenborg, Gerdina Hendrika Maria Pijnenborg   +61 more
doaj   +1 more source

Drivers of insect herbivory resistance and tolerance to plant damage in the Brachypodium distachyon species complex

American Journal of Botany, EarlyView.
Abstract Premise Insect herbivory is a major biotic factor shaping plant populations and driving the evolution of defensive traits. Polyploidy (whole‐genome duplication) often induces substantial phenotypic and genotypic changes that may affect species interactions, including herbivory.
Antonio J. Manzaneda, Luisa M. Martínez, Ana Fernández‐Ocaña, Teresa Salido, Pedro J. Rey   +4 more
wiley   +1 more source

Analysing Effects of Birth Order on Intelligence, Educational Attainment, Big Five, and Risk Aversion in an Indonesian Sample

European Journal of Personality, EarlyView., 2020
Abstract Few studies have examined birth order effects on personality in countries that are not Western, educated, industrialized, rich, and democratic (WEIRD). However, theories have generally suggested that interculturally universal family dynamics are the mechanism behind birth order effects, and prominent theories such as resource dilution would ...
Laura J. Botzet, Julia M. Rohrer, Ruben C. Arslan   +2 more
wiley   +1 more source

Does Managerial Ability Improve Environmental Performance and Overall ESG Ratings? The Impact of the European Sustainability Reporting Mandate

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examines the role of managerial ability in driving environmental performance and overall environmental, social, and governance (ESG) ratings in the context of the European Union sustainability reporting regulations. Using a sample of 7242 firm‐year observations over the period 2015–2023, our results indicate a structural change in ...
Mihaela Ionașcu, Ion Ionașcu, Elena Turuianu   +2 more
wiley   +1 more source