Results 31 to 40 of about 21,455 (221)

A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms.

PLoS ONE, 2019
Second-generation mammalian target of rapamycin (mTOR) inhibitors such as CC-223 may have theoretical advantages over first-generation drugs by inhibiting TOR kinase in mTOR complex 1 (mTORC1) and 2 (mTORC2), potentially improving clinical efficacy for ...
Edward Wolin, Alain Mita, Amit Mahipal, Tim Meyer, Johanna Bendell, John Nemunaitis, Pam N Munster, Luis Paz-Ares, Ellen H Filvaroff, Shaoyi Li, Kristen Hege, Hans de Haan, Monica Mita   +12 more
doaj   +1 more source

The Mice at play in the CALIFA survey: A case study of a gas-rich major merger between first passage and coalescence [PDF]

, 2014
We present optical integral field spectroscopy (IFS) observations of the Mice, a major merger between two massive (>10^11Msol) gas-rich spirals NGC4676A and B, observed between first passage and final coalescence.
Adriana de Lorenzo-Cáceres, Agertz, Aguerri, Alfonso L. Aguerri, Allen, Almudena Alonso Herrero, Alonso-Herrero, Ana Monreal-Ibero, Andreas Quirrenbach, Anna Gallazzi, Anna Pasquali, Ascensión del Olmo, Baldry, Barnes, Barnes, Barton, Begoña García Lorenzo, Benjamin D. Johnson, Bernd Husemann, Bernloehr, Bodo Ziegler, Boquien, Brinchmann, Bruzual, Burbidge, Bureau, Bureau, C. Jakob Walcher, Calzetti, Cappellari, Cappellari, Cardelli, Carolina Kehrig, Casoli, Chary, Chen, Chien, Cid Fernandes, Cid Fernandes, Cid Fernandes, Cid Fernandes, Cid Fernandes, Conroy, Contopoulos, Cortés, Cristina Catalán-Torrecilla, Dale, Damian Mast, Diamond-Stanic, Dominik J. Bomans, Engel, Enrique Peréz, Eracleous, Eracleous, Esther Mármol-Queraltó, Estrella Florido, Fabian Rosales-Ortega, Farage, Fogarty, Gadotti, Gallazzi, García-Lorenzo, Gerssen, Girardi, Glenn van de Ven, González Delgado, González-Martín, Grevesse, Groves, Groves, Haan, Heckman, Heckman, Helou, Hernquist, Hibbard, Hopkins, Husemann, Iglesias-Páramo, Isabel Márquez, Jairo Méndez-Abreu, Jean Michel Gomes, Jesus Falcón-Barroso, Johansson, Johansson, Jorge Barrera-Ballesteros, Jorge Iglesias-Páramo, Jose M. Vílchez, Joss Bland-Hawthorn, João Alves, Karl, Kauffmann, Keel, Kennicutt, Kennicutt, Kennicutt, Kewley, Kewley, Knud Jahnke, Kronberger, Kubo, Kuijken, Lambas, Leitherer, Mariya Lyubenova, Martin, Martins, Martínez-Valpuesta, Masegosa, Matteo, Mihos, Milena Pawlik, Morse, Murray, Navarro, Panter, Patrick Olden, Patton, Patton, Peng, Peter H. Johansson, Pettini, Pilyugin, Polychronis Papaderos, Pomarède, Privon, Raffaella A. Marino, Read, Relaño, Rich, Rich, Robaina, Robert C. Kennicutt, Roberto Cid Fernandes, Rosa M. González Delgado, Roth, Roussel, Rubén García-Benito, Rupke, Rupke, Saha, Schiminovich, Seaquist, Sebastian F. Sánchez, Sharp, Simien, Simona Bekeraité, Smith, Smith, Springel, Springel, Springel, Stasińska, Stockton, Sánchez, Sánchez, Sánchez, Sánchez-Blázquez, Teyssier, Thomas, Toomre, Valdes, Vazdekis, Veilleux, Vivienne Wild, Vorontsov-Vel’Iaminov, Weiner, Wild, Wild, Williams, Woods, Yun, Á. R. López-Sánchez   +172 more
core   +5 more sources

Modeling Defects, Shape Evolution, and Programmed Auto-origami in Liquid Crystal Elastomers [PDF]

, 2016
Liquid crystal elastomers represent a novel class of programmable shape-transforming materials whose shape change trajectory is encoded in the material's nematic director field.
Gimenez-Pinto, Vianney, Konya, Andrew, Selinger, Robin   +2 more
core   +2 more sources

Paracrine Factor Local Gradient‐Generating System for Engineering Perfusable Vascularized Hepatocyte Tissues with Perfusion‐Induced Proliferation

Advanced Healthcare Materials, EarlyView.
A paracrine factor local gradient (PFLG)‐generating system enables microvessel penetration across 3D hepatocyte tissues. The resulting vascularized constructs recapitulate hepatic sinusoidal hepatocyte—endothelial contact architecture and enhance hepatic functions in vitro.
Yen‐Hsiang Huang, Tadahiro Yamashita, Ryo Sudo   +2 more
wiley   +1 more source

A supermartingale argument for characterizing the Functional Hill process weak law for small parameters

, 2016
The paper deals with the asymptotic laws of functional of standard random variables. These classes of statistics are closely related to estimators of the extreme value index when the underlying distribution function is in the Weibull domain of attraction.
Adekpejou, Akym, Fall, Adja Mbarka, Lo, Gane Samb, Ndiaye, Cheikhna Hamallah   +3 more
core   +1 more source

Hybrid Magnetoactive Soft Elastomers: Material Development Toward Application in Diaphragm Pumps

Advanced Materials Technologies, EarlyView.
Hybrid magnetoactive soft elastomeric membranes are developed by combining two different types of magnetic particles. The membranes exhibit distinct mechanical, magnetic and thermal properties owing to the unique characteristics of the two magnetic particles.
Somashree Mondal, Paweł Orkisz, Bogdan Sapiński, Ralph Spolenak, Frank Clemens   +4 more
wiley   +1 more source

Efficacy of Acceptance and Commitment Therapy in Daily Life (ACT-DL) in early psychosis: study protocol for a multi-centre randomized controlled trial

Trials, 2019
Background Psychotic experiences, social functioning and general psychopathology are important targets for early intervention in individuals with Ultra-High-Risk state (UHR) and a first-episode psychosis (FEP).
Ulrich Reininghaus, Annelie Klippel, Henrietta Steinhart, Thomas Vaessen, Martine van Nierop, Wolfgang Viechtbauer, Tim Batink, Zuzana Kasanova, Evelyne van Aubel, Ruud van Winkel, Machteld Marcelis, Therese van Amelsvoort, Mark van der Gaag, Lieuwe de Haan, Inez Myin-Germeys   +14 more
doaj   +1 more source

High‐Power Rapid Laser‐Induced Synthesis of Multi‐functional Cobalt Metal‐Organic Framework With an Unprecedented Synthesis Efficiency

Advanced Materials Technologies, EarlyView.
Laser‐assisted synthesis enables rapid (within 1 h) and high‐yield (≥90%) production of Co‐MOFs with mesoporous structures, tunable magnetic and optical properties, and efficient adsorption of N2, CH4, and CO2 for low‐energy gas separation. DFT calculations elucidate the electronic structure and adsorption behavior.
Saliha Mutlu, Bülend Ortaç, Ali Karatutlu, Taylan Gorkan, Engin Durgun, Dilek Soyler, Saniye Soylemez, Jelena Lillepäg, Volkan Filiz, Nergis Arsu, Sevil Savaskan Yilmaz   +10 more
wiley   +1 more source

Individualized Prediction of Transition to Psychosis in 1,676 Individuals at Clinical High Risk: Development and Validation of a Multivariable Prediction Model Based on Individual Patient Data Meta-Analysis

Frontiers in Psychiatry, 2019
Background: The Clinical High Risk state for Psychosis (CHR-P) has become the cornerstone of modern preventive psychiatry. The next stage of clinical advancements rests on the ability to formulate a more accurate prognostic estimate at the individual ...
Aaltsje Malda, Aaltsje Malda, Nynke Boonstra, Nynke Boonstra, Hans Barf, Steven de Jong, Andre Aleman, Andre Aleman, Jean Addington, Marita Pruessner, Marita Pruessner, Dorien Nieman, Lieuwe de Haan, Anthony Morrison, Anthony Morrison, Anita Riecher-Rössler, Erich Studerus, Stephan Ruhrmann, Frauke Schultze-Lutter, Suk Kyoon An, Shinsuke Koike, Shinsuke Koike, Shinsuke Koike, Shinsuke Koike, Kiyoto Kasai, Kiyoto Kasai, Kiyoto Kasai, Kiyoto Kasai, Barnaby Nelson, Barnaby Nelson, Patrick McGorry, Patrick McGorry, Stephen Wood, Stephen Wood, Stephen Wood, Ashleigh Lin, Alison Y. Yung, Alison Y. Yung, Alison Y. Yung, Alison Y. Yung, Magdalena Kotlicka-Antczak, Marco Armando, Marco Armando, Stefano Vicari, Masahiro Katsura, Kazunori Matsumoto, Kazunori Matsumoto, Kazunori Matsumoto, Sarah Durston, Tim Ziermans, Tim Ziermans, Lex Wunderink, Lex Wunderink, Helga Ising, Mark van der Gaag, Mark van der Gaag, Paolo Fusar-Poli, Paolo Fusar-Poli, Paolo Fusar-Poli, Paolo Fusar-Poli, Gerdina Hendrika Maria Pijnenborg, Gerdina Hendrika Maria Pijnenborg   +61 more
doaj   +1 more source

Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics' [PDF]

, 2005
We combined large-scale mRNA expression analysis and gene mapping to identify genes and loci that control hematopoietic stem cell (HSC) function. We measured mRNA expression levels in purified HSCs isolated from a panel of densely genotyped recombinant ...
A Scherer, CE Muller-Sieburg, CS Potten, EE Schadt, ES Lander, F Lai, G de Haan, G De Haan, G De Haan, G Yvert, J Boultwood, J Klose, JL Peirce, LM Kamminga, M Ramalho-Santos, ML Wayne, NB Ivanova, NO Fortunel, P Hasty, RB Brem, RC Jansen, RC Jansen, SR Pearce, T Wiltshire, Y Ben-David   +24 more
core   +2 more sources