Results 11 to 20 of about 179 (77)

Kidney Injury Molecule‐1 and Cardiovascular Diseases: From Basic Science to Clinical Practice

BioMed Research International, Volume 2015, Issue 1, 2015., 2015
Despite the recent findings concerning pathogenesis and novel therapeutic strategies, cardiovascular disease (CVD) still stays the leading cause of morbidity and mortality in patients with renal dysfunction, especially acute kidney injury (AKI). Early detection of patients with impaired renal function with cardiovascular risk may help ensure more ...
Branislava Medić, Branislav Rovčanin, Gordana Basta Jovanović, Sanja Radojević-Škodrić, Milica Prostran, Hua Zhue   +5 more
wiley   +1 more source

Biological deep learning for simulating the role of SST Interneurons in cognitive resilience

Alzheimer's &Dementia, Volume 21, Issue S7, December 2025.
Abstract Background Two major snRNA‐seq studies have shown that SST interneurons specifically are lost along the AD disease trajectory (Gabitto et al., 2024, Mathys et al., 2023). We have previously shown that levels of SST‐14 peptide in the angular gyrus correlate with cognitive performance independent of AD pathology (Morgan & Carlyle, 2024).
Benjamin Federico Elias Duisberg, Iris Marmouset‐De La Taille, Will Greedy, Becky C. Carlyle, Rui Ponte Costa   +4 more
wiley   +1 more source

Binding characteristics of the doxepin E/Z‐isomers to the histamine H1 receptor revealed by receptor‐bound ligand analysis and molecular dynamics study

Journal of Molecular Recognition, Volume 37, Issue 5, September 2024.
Abstract Doxepin is an antihistamine and tricyclic antidepressant that binds to the histamine H1 receptor (H1R) with high affinity. Doxepin is an 85:15 mixture of the E‐ and Z‐isomers. The Z‐isomer is well known to be more effective than the E‐isomer, whereas based on the crystal structure of the H1R/doxepin complex, the hydroxyl group of Thr1123.37 is
Hiroto Kaneko, Ryunosuke Korenaga, Ryota Nakamura, Shinnosuke Kawai, Tadashi Ando, Mitsunori Shiroishi   +5 more
wiley   +1 more source

Geriatrics and Gastroenterology ‐ Time to Wake Up to the Ageing Problem

, 1990
Canadian Journal of Gastroenterology and Hepatology, Volume 4, Issue 6, Page 219-222, 1990.
ABR Thomson
wiley   +1 more source

Soluble immune checkpoint landscape in sickle cell disease links systemic inflammation, autoimmunity, and pain

Frontiers in Hematology
BackgroundSickle cell disease (SCD) is a chronic condition characterized by inflammation, immune dysregulation, and debilitating pain.AimThis study investigates soluble immune checkpoints (sICPs) and their associations with inflammatory mediators, immune
Wei Li, Andrew Q. Pucka, Lina Houran, Xiaoqing Huang, Candice Debats, Brandon A. Reyes, Andrew R. W. O’Brien, Qigui Yu, Ying Wang, Ying Wang   +9 more
doaj   +1 more source

Hereditary Tyrosinemia Type 1 Mice under Continuous Nitisinone Treatment Display Remnants of an Uncorrected Liver Disease Phenotype. [PDF]

Genes (Basel), 2023
Neuckermans J, Lequeue S, Claes P, Heymans A, Hughes JH, Colemonts-Vroninks H, Marcélis L, Casimir G, Goyens P, Martens GA, Gallagher JA, Vanhaecke T, Bou-Gharios G, De Kock J.   +13 more
europepmc   +1 more source

Targeted genome mining for microbial antitumor agents acting through DNA intercalation. [PDF]

Synth Syst Biotechnol, 2023
Zhao Z, Zhao G, Chai Y, Li W, Song K, Zhao W, Li H, Wu M, Zhou Z, Du YL.   +9 more
europepmc   +1 more source

First-in-Human Experience of Using a Universal Steerable Sheath in Implanting Left Atrial Appendage Closure Devices. [PDF]

JACC Asia, 2022
Chang SN, Chiu FC, Chen JJ, Huang PS, Lin TT, Cheng HL, Tsai CF, Wang YC, Tsai CT.   +8 more
europepmc   +1 more source

Atypical late-onset severe gastritis in immune dysregulation, polyendocrinopathy, enteropathy, and X-linked (IPEX) syndrome: 2 case reports. [PDF]

Medicine (Baltimore), 2021
Fang Y, Luo Y, Lou J, Chen J.
europepmc   +1 more source

C-C motif receptor 2 is a core profibrotic factor in uremic cardiomyopathy. [PDF]

Dis Model Mech
Bao JF, Guo BC, Mo JJ, Zhu H, Jia N, Hou F, Liu Y, Li A.   +7 more
europepmc   +1 more source