Results 81 to 90 of about 4,499,306 (241)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Analysis of Cavitation-induced Vibration Characteristics of a Vortex Pump Based on Adaptive Optimal Kernel Time-frequency Representation [PDF]

open access: yesJournal of Applied Fluid Mechanics
Cavitation-induced vibration presents a significant challenge in vortex pumps, leading to potential damage to hydraulic components and adverse effects on pump performance. This study aims to investigate the long-term implications of such phenomena.
Y. Wang   +4 more
doaj   +1 more source

Rank diversity of languages: Generic behavior in computational linguistics

open access: yes, 2015
Statistical studies of languages have focused on the rank-frequency distribution of words. Instead, we introduce here a measure of how word ranks change in time and call this distribution \emph{rank diversity}.
Cocho, Germinal   +4 more
core   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

A Time-Frequency Approach For EEG Spike Detection [PDF]

open access: yesIranica Journal of Energy and Environment, 2011
This paper presents a new method for detecting EEG spikes using the time-frequency distribution of the signal. As spikes are short-time broadband events, their energy patterns are represented as ridges in the time-frequency domain.
Hamid Hassanpour, Boualem Boashash
doaj  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

On accumulated Cohen's class distributions and mixed-state localization operators

open access: yes, 2018
Recently we introduced mixed-state localization operators associated to a density operator and a (compact) domain in phase space. We continue the investigations of their eigenvalues and eigenvectors.
Luef, Franz, Skrettingland, Eirik
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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