Results 161 to 170 of about 2,463,017 (252)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

FFT-RDNet: A Time-Frequency-Domain-Based Intrusion Detection Model for IoT Security. [PDF]

Sensors (Basel)
Xiang B, Zheng R, Zhang K, Li C, Zheng J.   +4 more
europepmc   +1 more source

EEG Changes in Time and Time-Frequency Domain During Movement Preparation and Execution in Stroke Patients. [PDF]

Front Neurosci, 2020
Li H, Huang G, Lin Q, Zhao J, Fu Q, Li L, Mao Y, Wei X, Yang W, Wang B, Zhang Z, Huang D.   +11 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Time-Frequency Domain Analysis of Quantitative Electroencephalography as a Biomarker for Dementia. [PDF]

Diagnostics (Basel)
Simfukwe C, An SSA, Youn YC.
europepmc   +1 more source

Graph-based feature extraction: A new proposal to study the classification of music signals outside the time-frequency domain. [PDF]

PLoS One, 2020
Melo DFP, Fadigas IS, Pereira HBB.
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Femtosecond spectroscopy with paired single photons: Emulating a double-slit experiment in the time-frequency domain. [PDF]

Sci Adv
Hong E, Jang E, Kim J.
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Rolling Bearing Fault Diagnosis via Meta-BOHB Optimized CNN-Transformer Model and Time-Frequency Domain Analysis. [PDF]

Sensors (Basel)
Wang Y, Jiang H, Tong B, Song S.
europepmc   +1 more source