Results 61 to 70 of about 12,651 (275)

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Towards a hardware implementation of ultra-wideband beamforming [PDF]

open access: yes, 2010
This paper discusses and analyses the hardware implementation of an ultra-wideband (UWB) beamformer for UWB Impulse Radio data transmission. We use a Complex Programmable Logic Device (CPLD) acting as the binary baseband information source.
Beach, MA   +4 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

A Microservices-Based Control Plane for Time-Sensitive Networking

open access: yesFuture Internet
Time-Sensitive Networking (TSN) aims to provide deterministic communications over Ethernet. The main characteristics of TSN are bounded latency and very high reliability, thus complying with the strict requirements of industrial communications or ...
Anna Agustí-Torra   +4 more
doaj   +1 more source

Hau [PDF]

open access: yes, 2007
The article presents reflections on some issues encountered when combining traditional Maori and Western concert music. These issues include tradition and repertoire versus innovation, control versus freedom, collaboration versus appropriation, and the ...
Lodge, Martin
core  

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Technology and Culture: Humans Inventing Themselves [PDF]

open access: yes, 2013
Since the ancient Greek myth of Prometheus who stole fire from the god, Zeus, humans have been befuddled by their own cleverness. We make useful tools and devices which seem to free humans for higher pursuits only to discover that the unintended ...
Haas, William Paul
core   +1 more source

Belle II Technical Design Report [PDF]

open access: yes, 2010
The Belle detector at the KEKB electron-positron collider has collected almost 1 billion Y(4S) events in its decade of operation. Super-KEKB, an upgrade of KEKB is under construction, to increase the luminosity by two orders of magnitude during a three ...
Abe, T.   +411 more
core   +1 more source

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